Gene Symbol | HIST1H2BO |
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Entrez Gene | 8348 |
Alt Symbol | H2B.2, H2B/n, H2BFN, dJ193B12.2 |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 1, H2bo |
Other Description | H2B histone family, member N|histone 1, H2bo|histone H2B type 1-O|histone H2B.2|histone H2B.n |
Swissprots | Q8TCV6 P23527 Q3KPI7 |
Accessions | AAN06698 CAA40416 EAX03124 P23527 BC106720 AAI06721 BX647290 EU446972 ABZ92501 NM_003527 NP_003518 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |
Histone cluster 1 H2BO CRISPR/Cas9 KO Plasmid (h) - sc-411150 from Santa Cruz Biotechnology
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Histone cluster 1 H2BO HDR Plasmid (h) - sc-411150-HDR from Santa Cruz Biotechnology
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Histone cluster 1 H2BO Double Nickase Plasmid (h) - sc-411150-NIC from Santa Cruz Biotechnology
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Histone cluster 1 H2BO Double Nickase Plasmid (h2) - sc-411150-NIC-2 from Santa Cruz Biotechnology
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Histone cluster 1 H2BO CRISPR Activation Plasmid (h) - sc-411150-ACT from Santa Cruz Biotechnology
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Histone cluster 1 H2BO CRISPR Activation Plasmid (h2) - sc-411150-ACT-2 from Santa Cruz Biotechnology
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Histone cluster 1 H2BO Lentiviral Activation Particles (h) - sc-411150-LAC from Santa Cruz Biotechnology
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Histone cluster 1 H2BO Lentiviral Activation Particles (h2) - sc-411150-LAC-2 from Santa Cruz Biotechnology
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Histone cluster 1 H2BO siRNA (h) - sc-105485 from Santa Cruz Biotechnology
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Histone cluster 1 H2BO shRNA Plasmid (h) - sc-105485-SH from Santa Cruz Biotechnology
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Histone cluster 1 H2BO shRNA (h) Lentiviral Particles - sc-105485-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10082 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10082 from Sigma-Aldrich
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HIST1H2BO siRNA (Human) - CRH5468 from Cohesion Biosciences
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HIST1H2BO RNAi - H00008348-R01 from Novus Biologicals
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HIST1H2BO - MBS8200677 from MyBioSource
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shRNA set against Human HIST1H2BO (NM_003527.4) - SHH312677 from Creative biogene
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HIST1H2BO shRNA Plasmid (Human) - CHH5468 from Cohesion Biosciences
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HIST1H2BO miRNA 3'UTR clone - MiUTR1H-04542 from Creative biogene
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