HGSNAT

Gene Symbol HGSNAT
Entrez Gene 138050
Alt Symbol HGNAT, MPS3C, TMEM76
Species Human
Gene Type protein-coding
Description heparan-alpha-glucosaminide N-acetyltransferase
Other Description transmembrane protein 76
Swissprots B4E2V0 Q68CP4
Accessions Q68CP4 AK025895 BAB15273 AK057293 BAB71412 AK074839 AK304441 BAG65262 AK308922 AL355714 AL832870 BC012452 AAH12452 BC042037 AAH42037 BC050672 BC056149 BE327420 CR457352 CAG33633 CR749838 CAH18694 DA395558 DB128369 XM_005273409 XP_005273466 XM_005273410 XP_005273467 XM_005273411 XP_005273468 XM_005273412 XP_005273469 NM_152419 NP_689632
Function Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:19823584, ECO:0000269|PubMed:20650889}.
Subcellular Location Lysosome membrane {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:17897319}. Note=Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain.
Tissue Specificity Widely expressed, with highest level in leukocytes, heart, liver, skeletal muscle, lung, placenta and liver. {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958}.
Top Pathways Lysosome, Glycosaminoglycan degradation

HGSNAT CRISPR/Cas9 KO Plasmid (h) - sc-407552 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGSNAT HDR Plasmid (h) - sc-407552-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGSNAT Double Nickase Plasmid (h) - sc-407552-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGSNAT Double Nickase Plasmid (h2) - sc-407552-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGSNAT CRISPR Activation Plasmid (h) - sc-407552-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGSNAT CRISPR Activation Plasmid (h2) - sc-407552-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGSNAT Lentiviral Activation Particles (h) - sc-407552-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGSNAT Lentiviral Activation Particles (h2) - sc-407552-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGSNAT siRNA (h) - sc-75251 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HGSNAT shRNA Plasmid (h) - sc-75251-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HGSNAT shRNA (h) Lentiviral Particles - sc-75251-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU019871 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10014 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10014 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HGSNAT siRNA (Human) - CRJ5214 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HGSNAT - MBS8208475 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HGSNAT (NM_152419.2) - SHH311945 from Creative biogene

Category siRNA
Species Reactivities Human

HGSNAT shRNA Plasmid (Human) - CHJ5214 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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