| Gene Symbol | EPOR |
|---|---|
| Entrez Gene | 2057 |
| Alt Symbol | EPO-R |
| Species | Human |
| Gene Type | protein-coding |
| Description | erythropoietin receptor |
| Other Description | - |
| Swissprots | Q2M205 B2RCG4 P19235 Q15443 |
| Accessions | AAA52392 AAA52393 AAB23271 AAB34703 ABX71216 AFM52330 AFM52331 EAW84205 EAW84206 EAW84207 EAW84208 P19235 AK315097 BAG37561 BC019092 BC112153 AAI12154 BC143697 BC143698 BC143700 BU619338 M34986 AAA52401 M60459 AAA52403 X57282 CAA40550 X97671 CAA66260 NM_000121 NP_000112 NR_033663 |
| Function | Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway |