Gene Symbol | TMLHE |
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Entrez Gene | 55217 |
Alt Symbol | AUTSX6, BBOX2, TMLD, TMLH, TMLHED, XAP130 |
Species | Human |
Gene Type | protein-coding |
Description | trimethyllysine hydroxylase, epsilon |
Other Description | TML hydroxylase|TML-alpha-ketoglutarate dioxygenase|butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 2|epsilon-trimethyllysine 2-oxoglutarate dioxygenase|epsilon-trimethyllysine hydroxylase|trimethyllysine dioxygenase, mitochondrial |
Swissprots | Q9NVH6 A8K6M9 Q8TBT0 Q6IA90 Q5TZB5 B4E3R3 |
Accessions | EAW55873 EAW55874 EAW55875 Q9NVH6 AF373407 AAL01871 AK001589 BAA91775 AK291694 BAF84383 AK304830 BAG65575 AK310667 AM393196 CAL38074 BC009673 BC025269 AAH25269 CR457265 CAG33546 DA323339 DB174485 XM_011531182 XP_011529484 XR_247318 NM_001184797 NP_001171726 NM_018196 NP_060666 |
Function | Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). |
Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:15754339}. |
Tissue Specificity | All isoforms, but isoform 8, are widely expressed in adult and fetal tissues. Isoform 8 is restricted to heart and skeletal muscle. {ECO:0000269|PubMed:15754339, ECO:0000269|PubMed:17408883}. |
Top Pathways | Lysine degradation |
TMLH CRISPR/Cas9 KO Plasmid (h) - sc-410000 from Santa Cruz Biotechnology
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TMLH HDR Plasmid (h) - sc-410000-HDR from Santa Cruz Biotechnology
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TMLH Double Nickase Plasmid (h) - sc-410000-NIC from Santa Cruz Biotechnology
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TMLH Double Nickase Plasmid (h2) - sc-410000-NIC-2 from Santa Cruz Biotechnology
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TMLH CRISPR Activation Plasmid (h) - sc-410000-ACT from Santa Cruz Biotechnology
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TMLH CRISPR Activation Plasmid (h2) - sc-410000-ACT-2 from Santa Cruz Biotechnology
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TMLH Lentiviral Activation Particles (h) - sc-410000-LAC from Santa Cruz Biotechnology
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TMLH Lentiviral Activation Particles (h2) - sc-410000-LAC-2 from Santa Cruz Biotechnology
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TMLH siRNA (h) - sc-91155 from Santa Cruz Biotechnology
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TMLH shRNA Plasmid (h) - sc-91155-SH from Santa Cruz Biotechnology
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TMLH shRNA (h) Lentiviral Particles - sc-91155-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU071741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2435 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2435 from Sigma-Aldrich
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TMLHE siRNA (Human) - CRJ0567 from Cohesion Biosciences
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TMLHE - MBS8214802 from MyBioSource
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shRNA set against Human TMLHE (NM_018196.3) - SHH431296 from Creative biogene
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Human TMLHE siRNA - orb271068 from Biorbyt
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TMLHE shRNA Plasmid (Human) - CHJ0567 from Cohesion Biosciences
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TMLHE miRNA 3'UTR clone - MiUTR3H-02939 from Creative biogene
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