GPRC6A

Gene Symbol	GPRC6A
Entrez Gene	222545
Alt Symbol	GPCR, bA86F4.3
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor, class C, group 6, member A
Other Description	G protein-coupled receptor, family C, group 6, member A|G-protein coupled receptor GPCR33|G-protein coupled receptor family C group 6 member A|predicted with SOSUI analysis|seven transmembrane helix receptor
Swissprots	Q8NHZ9 Q8TDT6 Q8NGU8 Q5T6X5 Q6JK43 Q6JK44
Accessions	BAB89328 BAC05904 CCF77881 CCF82064 EAW48214 Q5T6X5 AF502962 AAM22230 AW771483 AY435125 AAS13465 AY435126 AAS13466 AY435127 AAS13467 BC141419 AAI41420 BG191110 DY319308 NM_001286354 NP_001273283 NM_001286355 NP_001273284 NM_148963 NP_683766
Function	Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids. {ECO:0000269|PubMed:15576628, ECO:0000269|PubMed:20947496}.
Subcellular Location	Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity	Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues. {ECO:0000269|PubMed:15194188}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GPRC6A (M-166) - sc-67302 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

GPRC6A (H-68) - sc-67301 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

GPRC6A (S-17) - sc-55950 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-GPCR6A antibody - ab138994 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-GPCR6A antibody - ab96504 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-GPCR6A antibody - Extracellular domain - ab188768 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (N-Terminus) IHC-plus™ - LS-A2575 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (N-Terminus) - LS-C151718 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (C-Terminus) - LS-C151719 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa488-517, AP) - LS-C235956 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa488-517, APC) - LS-C235957 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa488-517, Biotin) - LS-C235958 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa862-926) - LS-C185957 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa471-520) - LS-C120707 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa488-517, FITC) - LS-C235959 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa488-517, PE) - LS-C235963 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa488-517, Azide-free, HRP) - LS-C249131 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa465-514) - LS-C292029 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa488-517) - LS-C321769 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (N-Terminus) IHC-plus™ - LS-A2581 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (aa489-517) IHC-plus™ - LS-B9471 from LifeSpan Bioscience Prices $395.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (N-Terminus) IHC-plus™ - LS-A2576 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPRC6A Antibody (N-Terminus) IHC-plus™ - LS-A2577 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

GPRC6A Antibody - NLS2576 from Novus Biologicals Prices $329.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

GPRC6A Antibody - NBP1-71071 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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