| Gene Symbol |
GPRC6A
|
| Entrez Gene |
222545
|
| Alt Symbol |
GPCR, bA86F4.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor, class C, group 6, member A
|
| Other Description |
G protein-coupled receptor, family C, group 6, member A|G-protein coupled receptor GPCR33|G-protein coupled receptor family C group 6 member A|predicted with SOSUI analysis|seven transmembrane helix receptor
|
| Swissprots |
Q8NHZ9 Q8TDT6 Q8NGU8 Q5T6X5 Q6JK43 Q6JK44
|
| Accessions |
BAB89328 BAC05904 CCF77881 CCF82064 EAW48214 Q5T6X5 AF502962 AAM22230 AW771483 AY435125 AAS13465 AY435126 AAS13466 AY435127 AAS13467 BC141419 AAI41420 BG191110 DY319308 NM_001286354 NP_001273283 NM_001286355 NP_001273284 NM_148963 NP_683766
|
| Function |
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids. {ECO:0000269|PubMed:15576628, ECO:0000269|PubMed:20947496}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues. {ECO:0000269|PubMed:15194188}.
|