KDR

Gene Symbol KDR
Entrez Gene 3791
Alt Symbol CD309, FLK1, VEGFR, VEGFR2
Species Human
Gene Type protein-coding
Description kinase insert domain receptor
Other Description fetal liver kinase 1|fetal liver kinase-1|kinase insert domain receptor (a type III receptor tyrosine kinase)|protein-tyrosine kinase receptor Flk-1|soluble VEGFR2|tyrosine kinase growth factor receptor|vascular endothelial growth factor receptor 2
Swissprots C5IFA0 P35968 Q14178 A2RRS0 O60723 B5A925
Accessions CAA61916 EAX05462 EAX05463 EAX05464 P35968 AB209901 BAD93138 AF035121 AAB88005 AF063658 AAC16450 AK293668 BAG57114 BC131822 AAI31823 BP280621 EU826563 ACF47599 FJ899739 ACR78514 L04947 AAA59459 X61656 CAA43837 NM_002253 NP_002244
Function Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of p
Subcellular Location Isoform 2: Secreted {ECO:0000305}.
Tissue Specificity Detected in cornea (at protein level). Widely expressed. {ECO:0000269|PubMed:19668192}.
Top Pathways Cytokine-cytokine receptor interaction, VEGF signaling pathway, Focal adhesion, Endocytosis, PI3K-Akt signaling pathway

KDR 293 Cell Lysate - 400788 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

VEGF R2/KDR/Flk-1 Overexpression Lysate (Native) - NBL1-06701 from Novus Biologicals

Category Cell Lysate
Prices $129.00
Sizes 100 µl
Western Blot: VEGF Receptor 2 Overexpression Lysate [NBL1-06701] - Western Blot on VEGFR2 overexpression lysates.

KDR Over-expression Lysate Product - GWB-82B536 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

Human VEGFR2 / Flk-1 / CD309 / KDR Insect Cell Lysate (WB positive control) - 10012-H20B1L-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human VEGFR2 / Flk-1 / CD309 / KDR HEK293 Cell Lysate (WB positive control) - 10012-H08HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human VEGFR2 / Flk-1 / CD309 / KDR HEK293 Cell Lysate (WB positive control) - 10012-H02HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human VEGFR2 Human Cells Transfected Lysate (positive control) (denatured) - orb173948 from Biorbyt

Category Cell Lysate
Prices $425.00
Sizes 300 μg
Species Human

Human VEGFR2 Human Cells Transfected Lysate (positive control) (denatured) - orb173115 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human KDR Knockdown Stable Cell Line - CSC-DC008057 from Creative biogene

Category Cell Line
Species Human
Search more