KDR

Gene Symbol	KDR
Entrez Gene	3791
Alt Symbol	CD309, FLK1, VEGFR, VEGFR2
Species	Human
Gene Type	protein-coding
Description	kinase insert domain receptor
Other Description	fetal liver kinase 1|fetal liver kinase-1|kinase insert domain receptor (a type III receptor tyrosine kinase)|protein-tyrosine kinase receptor Flk-1|soluble VEGFR2|tyrosine kinase growth factor receptor|vascular endothelial growth factor receptor 2
Swissprots	C5IFA0 P35968 Q14178 A2RRS0 O60723 B5A925
Accessions	CAA61916 EAX05462 EAX05463 EAX05464 P35968 AB209901 BAD93138 AF035121 AAB88005 AF063658 AAC16450 AK293668 BAG57114 BC131822 AAI31823 BP280621 EU826563 ACF47599 FJ899739 ACR78514 L04947 AAA59459 X61656 CAA43837 NM_002253 NP_002244
Function	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of p
Subcellular Location	Isoform 2: Secreted {ECO:0000305}.
Tissue Specificity	Detected in cornea (at protein level). Widely expressed. {ECO:0000269|PubMed:19668192}.
Top Pathways	Cytokine-cytokine receptor interaction, VEGF signaling pathway, Focal adhesion, Endocytosis, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human VEGF Receptor 2 full length protein - ab42614 from Abcam Category Protein Prices $326.00 Sizes 10 µg Source Baculovirus Species Human

Active human VEGF Receptor 2 protein fragment - ab155628 from Abcam Category Protein Prices $465.00 Sizes 200 µg Source HEK 293 cells Species Human

Active human VEGF Receptor 2 protein fragment - ab54347 from Abcam Category Protein Prices $122.00 Sizes 5 µg Source Insect cells Species Human

Active mouse VEGF Receptor 2 protein fragment - ab134453 from Abcam Category Protein Prices $643.00 Sizes 20 µg Source Insect cells Species Mouse

Human VEGF Receptor 2 full length protein - ab106310 from Abcam Category Protein Source Insect cells Species Human

Human VEGF Receptor 2 peptide - ab39255 from Abcam Category Peptide

Human VEGF Receptor 2 protein fragment - ab158790 from Abcam Category Protein Source Wheat germ Species Human

Human VEGF Receptor 2 protein fragment - ab54259 from Abcam Category Protein Source Insect cells Species Human

KDR / VEGFR2 / FLK1 Antibody Blocking Peptide - LS-E3745 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KDR / VEGFR2 / FLK1 Antibody Blocking Peptide - LS-E10635 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KDR / VEGFR2 / FLK1 Antibody Blocking Peptide - LS-E7274 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KDR / VEGFR2 / FLK1 Antibody Blocking Peptide - LS-E7465 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KDR / VEGFR2 / FLK1 Antibody Blocking Peptide - LS-E9144 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KDR / VEGFR2 / FLK1 Antibody Blocking Peptide - LS-E29657 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

KDR / VEGFR2 / FLK1 Antibody Blocking Peptide - LS-E29658 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

VEGF R2/KDR/Flk-1 Blocking Peptide - NB100-2382PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

VEGF R2/KDR/Flk-1 Partial Recombinant Protein - H00003791-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human VEGF R2/KDR/Flk-1 Protein - P3871 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Source Insect Species Human

VEGF R2/KDR/Flk-1 Recombinant Protein - P4793 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Human VEGF R2/KDR/Flk-1 Protein - NBP1-99411 from Novus Biologicals Category Protein Prices $190.00 Sizes 10 µg Source Insect cells Species Human

VEGF R2/KDR/Flk-1 Protein - NBP2-12565 from Novus Biologicals Category Protein Species Human

VEGF R2/KDR/Flk-1 Peptide - P1323 from Novus Biologicals Category Peptide Species Human

Phospho-KDRFLK1Y996-Antibody-Blocking-peptide - BP3107a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-KDRY1175-Antibody-Blocking-peptide - BP3710a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

KDR-Y1175-Antibody-Blocking-Peptide - BP7643c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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