EPHA7

Gene Symbol	EPHA7
Entrez Gene	2045
Alt Symbol	EHK-3, EHK3, EK11, HEK11
Species	Human
Gene Type	protein-coding
Description	EPH receptor A7
Other Description	EPH homology kinase 3|EPH-like kinase 11|Eph homology kinase-3|ephrin type-A receptor 7|receptor protein-tyrosine kinase HEK11|tyrosine-protein kinase receptor EHK-3
Swissprots	B7ZLJ9 Q8N368 A0AUX7 Q15375 Q5VTU0 Q59G40 B2R8W1 B7ZLK0 Q9H124
Accessions	CAT16938 CCQ43263 EAW48518 EAW48519 EAW48520 EAW48521 Q15375 AB209269 BAD92506 AK313529 BAG36308 AL699163 BC027940 AAH27940 BC126125 AAI26126 BC126151 AAI26152 BC143857 AAI43858 BC143858 AAI43859 BM677016 DA503795 L36642 AAA74243 XM_005248669 XP_005248726 XM_005248671 XP_005248728 NM_001288629 NP_001275558 NM_001288630 NP_001275559 NM_004440 NP_004431
Function	Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of E
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Widely expressed.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Eph receptor A7 full length protein - ab114687 from Abcam Category Protein Source Wheat germ Species Human

Human Eph receptor A7 protein fragment - ab158373 from Abcam Category Protein Source Wheat germ Species Human

Human Eph receptor A7 protein fragment - ab174075 from Abcam Category Protein Source HEK 293 cells Species Human

EPHA7 / EPH Receptor A7 Antibody Blocking Peptide - LS-E3913 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA7 / EPH Receptor A7 Antibody Blocking Peptide - LS-E9107 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA7 / EPH Receptor A7 Antibody Blocking Peptide - LS-E23279 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EphA7 Protein - H00002045-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human EphA7 Protein - H00002045-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EphA7 Recombinant Protein - P4681 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

EphA7 Peptide - P2628 from Novus Biologicals Category Peptide Species Human

EphA7-Antibody-C-term-Blocking-Peptide - BP7612b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Mouse EphA7 Fc Chimera, CF - 608-A7-200 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human EphA7 Fc Chimera, CF - 6756-A7-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human EPHA7 protein - orb163363 from Biorbyt Category Protein Prices $289.00, $400.00, $1,326.00, $1,981.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

EPHA7 - H00002045-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EPHA7 - H00002045-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EPHA7 - H00002045-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EPHA7 - H00002045-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EPHA7 - P4681 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

EPHA7 - P5707 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

EHK3 Recombinant Protein - 96-269 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

EPHA7 fusion protein - Ag3813 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human EPHA7 Protein - BP002662-C519 from Syd Labs Category Protein Prices $98.00, $252.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human EPH Receptor A7, GST-tagged - EPHA7-697H from Creative Biomart Category Protein Source Insect cells.

Recombinant Human EPHA7, His tagged - EPHA7-3228H from Creative Biomart Category Protein Source Human Cells Species Human

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