| Gene Symbol |
BAZ1A
|
| Entrez Gene |
11177
|
| Alt Symbol |
ACF1, WALp1, WCRF180, hACF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
bromodomain adjacent to zinc finger domain, 1A
|
| Other Description |
ATP-dependent chromatin remodeling protein|ATP-dependent chromatin-remodeling protein|ATP-utilizing chromatin assembly and remodeling factor 1|CHRAC subunit ACF1|bromodomain adjacent to zinc finger domain protein 1A|hWALp1|williams syndrome transcription factor-related chromatin-remodeling factor 180
|
| Swissprots |
Q9NZ15 Q9P065 Q9UIG1 Q9NRL2 Q9Y3V3
|
| Accessions |
CBX47567 CBX47568 EAW65900 EAW65901 EAW65902 EAW65903 EAW65904 EAW65905 Q9NRL2 AB032252 BAA89209 AB209255 BAD92492 AF086397 AF161435 AAF28995 AF213467 AAF70601 AF221130 AAF32366 AK027289 BAG51300 AL050089 CAB43261 BC020636 AAH20636 BC108711 AAI08712 BC156491 AAI56492 CB217757 XM_011536374 XP_011534676 XM_011536375 XP_011534677 XM_011536376 XP_011534678 XR_943381 NM_013448 NP_038476 NM_182648 NP_872589
|
| Function |
Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end- positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.
|
| Subcellular Location |
Nucleus. Note=May target the CHRAC complex to heterochromatin.
|
| Tissue Specificity |
Highly expressed in testis and at low or undetectable levels in other tissues analyzed.
|