BAZ1A
| Gene Symbol | BAZ1A |
|---|---|
| Entrez Gene | 11177 |
| Alt Symbol | ACF1, WALp1, WCRF180, hACF1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | bromodomain adjacent to zinc finger domain, 1A |
| Other Description | ATP-dependent chromatin remodeling protein|ATP-dependent chromatin-remodeling protein|ATP-utilizing chromatin assembly and remodeling factor 1|CHRAC subunit ACF1|bromodomain adjacent to zinc finger domain protein 1A|hWALp1|williams syndrome transcription factor-related chromatin-remodeling factor 180 |
| Swissprots | Q9NZ15 Q9P065 Q9UIG1 Q9NRL2 Q9Y3V3 |
| Accessions | CBX47567 CBX47568 EAW65900 EAW65901 EAW65902 EAW65903 EAW65904 EAW65905 Q9NRL2 AB032252 BAA89209 AB209255 BAD92492 AF086397 AF161435 AAF28995 AF213467 AAF70601 AF221130 AAF32366 AK027289 BAG51300 AL050089 CAB43261 BC020636 AAH20636 BC108711 AAI08712 BC156491 AAI56492 CB217757 XM_011536374 XP_011534676 XM_011536375 XP_011534677 XM_011536376 XP_011534678 XR_943381 NM_013448 NP_038476 NM_182648 NP_872589 |
| Function | Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end- positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. |
| Subcellular Location | Nucleus. Note=May target the CHRAC complex to heterochromatin. |
| Tissue Specificity | Highly expressed in testis and at low or undetectable levels in other tissues analyzed. |
WCRF CRISPR/Cas9 KO Plasmid (h) - sc-407304 from Santa Cruz Biotechnology
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WCRF HDR Plasmid (h) - sc-407304-HDR from Santa Cruz Biotechnology
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WCRF Double Nickase Plasmid (h) - sc-407304-NIC from Santa Cruz Biotechnology
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WCRF Double Nickase Plasmid (h2) - sc-407304-NIC-2 from Santa Cruz Biotechnology
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WCRF CRISPR Activation Plasmid (h) - sc-407304-ACT from Santa Cruz Biotechnology
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WCRF CRISPR Activation Plasmid (h2) - sc-407304-ACT-2 from Santa Cruz Biotechnology
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WCRF Lentiviral Activation Particles (h) - sc-407304-LAC from Santa Cruz Biotechnology
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WCRF Lentiviral Activation Particles (h2) - sc-407304-LAC-2 from Santa Cruz Biotechnology
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BAZ1A siRNA (h) - sc-38623 from Santa Cruz Biotechnology
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BAZ1A shRNA Plasmid (h) - sc-38623-SH from Santa Cruz Biotechnology
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BAZ1A shRNA (h) Lentiviral Particles - sc-38623-V from Santa Cruz Biotechnology
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ACF1 RNAi - H00011177-R01 from Novus Biologicals
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ACF1 RNAi - H00011177-R02 from Novus Biologicals
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MISSION® esiRNA - EHU085431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3872 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3872 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06828 from Sigma-Aldrich
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BAZ1A siRNA (Human) - CRH7657 from Cohesion Biosciences
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BAZ1A - MBS827516 from MyBioSource
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WCRF CRISPR/Cas9 KO Plasmid (h2) - sc-407304-KO-2 from Santa Cruz Biotechnology
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WCRF HDR Plasmid (h2) - sc-407304-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human BAZ1A (NM_182648.1) - SHH245022 from Creative biogene
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shRNA set against Human BAZ1A(NM_013448.2) - SHG091961 from Creative biogene
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shRNA set against Human BAZ1A(NM_182648.1) - SHG091979 from Creative biogene
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Human BAZ1A siRNA - orb268159 from Biorbyt
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