Gene Symbol |
SNIP1
|
Entrez Gene |
79753
|
Alt Symbol |
PMRED
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
Smad nuclear interacting protein 1
|
Other Description |
FHA domain-containing protein SNIP1|smad nuclear-interacting protein 1
|
Swissprots |
Q96SP9 Q8TAD8 Q9H9T7
|
Accessions |
EAX07338 Q8TAD8 AK022615 BAB14134 AK027622 BAB55241 AK293229 BAG56768 AK297176 BAG59668 AK300796 BAG62455 AK315574 BAG37948 AY081909 AAL91140 BC027040 AAH27040 BP364813 CX759814 HQ447254 ADQ31741 XM_011542160 XP_011540462 NM_024700 NP_078976
|
Function |
Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151}.
|
Subcellular Location |
Nucleus {ECO:0000269|PubMed:10887155}.
|
Tissue Specificity |
Ubiquitous, with highest expression in heart and skeletal muscle. {ECO:0000269|PubMed:10887155}.
|