Gene Symbol | SNIP1 |
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Entrez Gene | 79753 |
Alt Symbol | PMRED |
Species | Human |
Gene Type | protein-coding |
Description | Smad nuclear interacting protein 1 |
Other Description | FHA domain-containing protein SNIP1|smad nuclear-interacting protein 1 |
Swissprots | Q96SP9 Q8TAD8 Q9H9T7 |
Accessions | EAX07338 Q8TAD8 AK022615 BAB14134 AK027622 BAB55241 AK293229 BAG56768 AK297176 BAG59668 AK300796 BAG62455 AK315574 BAG37948 AY081909 AAL91140 BC027040 AAH27040 BP364813 CX759814 HQ447254 ADQ31741 XM_011542160 XP_011540462 NM_024700 NP_078976 |
Function | Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10887155}. |
Tissue Specificity | Ubiquitous, with highest expression in heart and skeletal muscle. {ECO:0000269|PubMed:10887155}. |
SNIP1 CRISPR/Cas9 KO Plasmid (h) - sc-406181 from Santa Cruz Biotechnology
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SNIP1 HDR Plasmid (h) - sc-406181-HDR from Santa Cruz Biotechnology
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SNIP1 Double Nickase Plasmid (h) - sc-406181-NIC from Santa Cruz Biotechnology
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SNIP1 Double Nickase Plasmid (h2) - sc-406181-NIC-2 from Santa Cruz Biotechnology
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SNIP1 CRISPR Activation Plasmid (h) - sc-406181-ACT from Santa Cruz Biotechnology
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SNIP1 CRISPR Activation Plasmid (h2) - sc-406181-ACT-2 from Santa Cruz Biotechnology
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SNIP1 Lentiviral Activation Particles (h) - sc-406181-LAC from Santa Cruz Biotechnology
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SNIP1 Lentiviral Activation Particles (h2) - sc-406181-LAC-2 from Santa Cruz Biotechnology
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SNIP1 siRNA (h) - sc-61581 from Santa Cruz Biotechnology
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SNIP1 shRNA Plasmid (h) - sc-61581-SH from Santa Cruz Biotechnology
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SNIP1 shRNA (h) Lentiviral Particles - sc-61581-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU046241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19873 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19873 from Sigma-Aldrich
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SNIP1 siRNA (Human) - CRJ2541 from Cohesion Biosciences
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SNIP1 - MBS8230053 from MyBioSource
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shRNA set against Human SNIP (NM_024700.3) - SHH414128 from Creative biogene
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Human SNIP1 siRNA - orb273042 from Biorbyt
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SNIP1 shRNA Plasmid (Human) - CHJ2541 from Cohesion Biosciences
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SNIP1 miRNA 3'UTR clone - MiUTR3H-09864 from Creative biogene
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