| Gene Symbol |
FILIP1L
|
| Entrez Gene |
11259
|
| Alt Symbol |
DOC-1, DOC1, GIP130, GIP90
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
filamin A interacting protein 1-like
|
| Other Description |
130 kDa GPBP-interacting protein|90 kDa GPBP-interacting protein|filamin A-interacting protein 1-like|protein down-regulated in ovarian cancer 1
|
| Swissprots |
B2CNV7 Q6KFX7 Q2YDY5 B2CNV8 Q6KFX5 Q6KFX6 Q8IUM3 Q8N6Z0 Q4L180 Q13597
|
| Accessions |
EAW79833 EAW79834 Q4L180 AF329092 AAN16206 AF514867 AAQ08177 AF514868 AAQ08178 AF514869 AAQ08179 AK096195 AK225855 AX776292 CAE11726 AX776294 CAE11727 AX776296 CAE11728 AX776298 CAE11729 AY642382 AAV34207 BC017987 BC020941 AAH20941 BC027860 AAH27860 BM674194 BP233250 DB080427 EU531865 ACB37436 EU531866 ACB37437 U53445 AAA98972 XM_006713486 XP_006713549 XM_011512371 XP_011510673 NM_001042459 NP_001035924 NM_001282793 NP_001269722 NM_001282794 NP_001269723 NM_014890 NP_055705 NM_182909 NP_878913
|
| Function |
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor- associated vasculature. {ECO:0000269|PubMed:18794120}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18794120}. Membrane {ECO:0000269|PubMed:18794120}. Nucleus {ECO:0000269|PubMed:18794120}.
|
| Tissue Specificity |
Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer. {ECO:0000269|PubMed:18794120, ECO:0000269|PubMed:8314147}.
|