| Gene Symbol |
SCUBE1
|
| Entrez Gene |
80274
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signal peptide, CUB domain, EGF-like 1
|
| Other Description |
signal peptide, CUB and EGF-like domain-containing protein 1|signal peptide-CUB domain-EGF-related 1
|
| Swissprots |
Q5R336 Q8IWY4
|
| Accessions |
EAW73295 EAW73296 EAW73297 EAW73298 EAW73299 EAW73300 EAW73301 EAW73302 Q8IWY4 AF525689 AAN77133 AK127719 BAC87098 BC047916 AAH47916 BC127263 AAI27264 BC156731 AAI56732 BG901065 BM714681 BQ183912 BU101852 BX280767 DN991996 DR003420 XM_005261752 XP_005261809 XM_011530389 XP_011528691 XM_011530390 XP_011528692 XM_011530391 XP_011528693 NM_173050 NP_766638
|
| Function |
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. {ECO:0000269|PubMed:16753137}.
|
| Subcellular Location |
Secreted. Cell membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques. {ECO:0000269|PubMed:12270931, ECO:0000269|PubMed:16753137}.
|