| Gene Symbol | NR4A2 |
|---|---|
| Entrez Gene | 4929 |
| Alt Symbol | HZF-3, NOT, NURR1, RNR1, TINUR |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear receptor subfamily 4, group A, member 2 |
| Other Description | NGFI-B/nur77 beta-type transcription factor homolog|T-cell nuclear receptor NOT|immediate-early response protein NOT|intermediate-early receptor protein|nuclear receptor related 1|nuclear receptor subfamily 4 group A member 2|nur related protein-1, human homolog of|orphan nuclear receptor NR4A2|orphan nuclear receptor NURR1|transcriptionally inducible nuclear receptor related 1|transcriptionally-inducible nuclear receptor |
| Swissprots | Q53RZ2 P43354 Q6NXU0 Q16311 |
| Accessions | AAY24203 BAA75666 BAA77328 CBX47656 CBX47659 EAX11454 EAX11455 P43354 AK223625 BAD97345 AK291456 BAF84145 AK299439 BAH13033 AK309786 BC009288 AAH09288 BC066890 AAH66890 BM922519 DA093733 EU832662 ACE87753 EU832740 ACE87072 FJ643484 ACN32470 FJ643485 ACN32471 HQ692824 ADZ17335 HQ709176 ADZ17383 S77154 AAB33999 X75918 CAA53518 XM_005246621 XP_005246678 XM_005246622 XP_005246679 XM_005246623 XP_005246680 XM_006712553 XP_006712616 XM_011511246 XP_011509548 XR_427087 NM_006186 NP_006177 NM_173171 NM_173172 NM_173173 |
| Function | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization. |
| Tissue Specificity | Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. |