Gene Symbol | CYP39A1 |
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Entrez Gene | 51302 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Other Description | 24-hydroxycholesterol 7-alpha-hydroxylase|cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1 |
Swissprots | Q96FW5 Q5VTT0 Q9NYL5 |
Accessions | EAX04297 Q9NYL5 AF237982 AAF63329 AK292263 BAF84952 AK301604 BAH13522 AK307986 BC010358 AAH10358 BC012548 BC034323 BG199773 DC336695 DQ892889 ABM83815 EU176719 ABW03520 XM_005249171 XP_005249228 XM_011514655 XP_011512957 XM_011514656 XP_011512958 XM_011514657 XP_011512959 XM_011514658 XP_011512960 NM_001278738 NP_001265667 NM_001278739 NP_001265668 NM_016593 NP_057677 |
Function | Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Tissue Specificity | Liver specific. |
Top Pathways | Primary bile acid biosynthesis |
CYP39A1 CRISPR/Cas9 KO Plasmid (h) - sc-408603 from Santa Cruz Biotechnology
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CYP39A1 HDR Plasmid (h) - sc-408603-HDR from Santa Cruz Biotechnology
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CYP39A1 Double Nickase Plasmid (h) - sc-408603-NIC from Santa Cruz Biotechnology
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CYP39A1 Double Nickase Plasmid (h2) - sc-408603-NIC-2 from Santa Cruz Biotechnology
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CYP39A1 CRISPR Activation Plasmid (h) - sc-408603-ACT from Santa Cruz Biotechnology
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CYP39A1 CRISPR Activation Plasmid (h2) - sc-408603-ACT-2 from Santa Cruz Biotechnology
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CYP39A1 Lentiviral Activation Particles (h) - sc-408603-LAC from Santa Cruz Biotechnology
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CYP39A1 Lentiviral Activation Particles (h2) - sc-408603-LAC-2 from Santa Cruz Biotechnology
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CYP39A1 siRNA (h) - sc-95490 from Santa Cruz Biotechnology
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CYP39A1 shRNA Plasmid (h) - sc-95490-SH from Santa Cruz Biotechnology
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CYP39A1 shRNA (h) Lentiviral Particles - sc-95490-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU025011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2418 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2418 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05661 from Sigma-Aldrich
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CYP39A1 siRNA (Human) - CRH9679 from Cohesion Biosciences
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CYP39A1 RNAi - H00051302-R01 from Novus Biologicals
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CYP39A1 - MBS8234405 from MyBioSource
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shRNA set against Human CYP39A1 (NM_016593.3) - SHH273433 from Creative biogene
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shRNA set against Human CYP39A1(NM_016593.3) - SHG217423 from Creative biogene
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CYP39A1 shRNA Plasmid (Human) - CHH9679 from Cohesion Biosciences
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CYP39A1 miRNA 3'UTR clone - MiUTR1H-02630 from Creative biogene
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