Gene Symbol | EEF2 |
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Entrez Gene | 1938 |
Alt Symbol | EEF-2, EF-2, EF2, SCA26 |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic translation elongation factor 2 |
Other Description | elongation factor 2|polypeptidyl-tRNA translocase |
Swissprots | D6W618 P13639 Q58J86 B2RMP5 |
Accessions | EAW69274 EAW69275 P13639 AK297398 BAG59838 AK298498 BAG60705 AK299225 BAG61260 AU118535 AY942181 AAX34409 BC006547 AAH06547 BC024689 AAH24689 BC126259 AAI26260 BC136313 AAI36314 HQ258667 ADR83418 M19997 AAA50388 X51466 CAA35829 Z11692 CAA77750 NM_001961 NP_001952 |
Function | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. |
Subcellular Location | Cytoplasm. Nucleus {ECO:0000269|PubMed:24648518}. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. {ECO:0000269|PubMed:24648518}. |
Top Pathways | Oxytocin signaling pathway, AMPK signaling pathway |
EF-2 CRISPR/Cas9 KO Plasmid (h) - sc-401163 from Santa Cruz Biotechnology
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EF-2 HDR Plasmid (h) - sc-401163-HDR from Santa Cruz Biotechnology
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EF-2 Double Nickase Plasmid (h) - sc-401163-NIC from Santa Cruz Biotechnology
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EF-2 Double Nickase Plasmid (h2) - sc-401163-NIC-2 from Santa Cruz Biotechnology
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EF-2 CRISPR Activation Plasmid (h) - sc-401163-ACT from Santa Cruz Biotechnology
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EF-2 CRISPR Activation Plasmid (h2) - sc-401163-ACT-2 from Santa Cruz Biotechnology
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EF-2 Lentiviral Activation Particles (h) - sc-401163-LAC from Santa Cruz Biotechnology
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EF-2 Lentiviral Activation Particles (h2) - sc-401163-LAC-2 from Santa Cruz Biotechnology
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EF-2 siRNA (h) - sc-43541 from Santa Cruz Biotechnology
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EF-2 shRNA Plasmid (h) - sc-43541-SH from Santa Cruz Biotechnology
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EF-2 shRNA (h) Lentiviral Particles - sc-43541-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU047821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7671 from Sigma-Aldrich
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EEF2 siRNA (Human) - CRH1337 from Cohesion Biosciences
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EEF2 - MBS8235770 from MyBioSource
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shRNA set against Human Eef2 (NM_001961.3) - SHH283337 from Creative biogene
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shRNA set against Human EEF2(NM_001961.3) - SHH024851 from Creative biogene
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Human EEF2 siRNA - orb261839 from Biorbyt
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EEF2 shRNA Plasmid (Human) - CHH1337 from Cohesion Biosciences
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EEF2 miRNA 3'UTR clone - MiUTR1H-03116 from Creative biogene
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