Gene Symbol | RXRG |
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Entrez Gene | 6258 |
Alt Symbol | NR2B3, RXRC |
Species | Human |
Gene Type | protein-coding |
Description | retinoid X receptor, gamma |
Other Description | nuclear receptor subfamily 2 group B member 3|retinoic acid receptor RXR-gamma |
Swissprots | P48443 Q6IBU7 A6NIP1 |
Accessions | EAW90745 P48443 AB307706 BAH02297 AB593015 BAJ83970 AB593016 BAJ83971 AK125497 AK312922 BAG35767 AL538345 BC012063 AAH12063 BE349162 BI768747 BM684530 BM728015 BX118484 CR456705 CAG32986 DA251671 DA893476 EU831976 ACE87417 EU832069 ACE86731 HQ692845 ADZ17356 U38480 AAA80681 NM_001256570 NP_001243499 NM_001256571 NP_001243500 NM_006917 NP_008848 NR_033824 |
Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. |
Top Pathways | Small cell lung cancer, Non-small cell lung cancer, Adipocytokine signaling pathway, PPAR signaling pathway, Thyroid cancer |
RXRγ CRISPR/Cas9 KO Plasmid (h) - sc-401816 from Santa Cruz Biotechnology
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RXRγ HDR Plasmid (h) - sc-401816-HDR from Santa Cruz Biotechnology
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RXRγ Double Nickase Plasmid (h) - sc-401816-NIC from Santa Cruz Biotechnology
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RXRγ Double Nickase Plasmid (h2) - sc-401816-NIC-2 from Santa Cruz Biotechnology
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RXRγ CRISPR Activation Plasmid (h) - sc-401816-ACT from Santa Cruz Biotechnology
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RXRγ CRISPR Activation Plasmid (h2) - sc-401816-ACT-2 from Santa Cruz Biotechnology
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RXRγ Lentiviral Activation Particles (h) - sc-401816-LAC from Santa Cruz Biotechnology
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RXRγ Lentiviral Activation Particles (h2) - sc-401816-LAC-2 from Santa Cruz Biotechnology
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RXRγ siRNA (h2) - sc-270445 from Santa Cruz Biotechnology
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RXRγ shRNA Plasmid (h2) - sc-270445-SH from Santa Cruz Biotechnology
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RXRγ shRNA (h2) Lentiviral Particles - sc-270445-V from Santa Cruz Biotechnology
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RXR gamma/NR2B3 RNAi - H00006258-R01 from Novus Biologicals
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RXR gamma/NR2B3 RNAi - H00006258-R02 from Novus Biologicals
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MISSION® esiRNA - EHU064981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18775 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18775 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01413 from Sigma-Aldrich
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RXRG siRNA (Human) - CRH4214 from Cohesion Biosciences
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RXRG - MBS8214707 from MyBioSource
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shRNA set against Human RXRG (NM_006917.4) - SHH400996 from Creative biogene
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RXRG shRNA Plasmid (Human) - CHH4214 from Cohesion Biosciences
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RXRG miRNA 3'UTR clone - MiUTR3H-02034 from Creative biogene
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