| Gene Symbol |
SIK2
|
| Entrez Gene |
23235
|
| Alt Symbol |
LOH11CR1I, QIK, SIK-2, SNF1LK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
salt-inducible kinase 2
|
| Other Description |
SNF1-like kinase 2|qin-induced kinase|salt-inducible protein kinase 2|salt-inducible serine/threonine kinase 2|serine/threonine-protein kinase SIK2|serine/threonine-protein kinase SNF1-like kinase 2
|
| Swissprots |
Q9H0K1 Q6AZE2 O94878 B0YJ94 Q17RV0 A8K5B8 Q76N03 Q96CZ8 Q8NCV7
|
| Accessions |
ACA06072 EAW67146 EAW67147 EAW67148 EAW67149 Q9H0K1 AB018324 BAA34501 AB084424 BAB91442 AB096248 AK000396 AK096463 AK291233 BAF83922 AL136764 CAB66698 BC013612 AAH13612 BC078150 AAH78150 BC113459 AAI13460 BC117183 AAI17184 BM799630 BM982514 BU621749 CB124295 DA333935 XM_011542716 XP_011541018 XM_011542717 XP_011541019 NM_015191 NP_056006
|
| Function |
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. {ECO:0000269|PubMed:15454081}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Glucagon signaling pathway
|