| Gene Symbol | Ccl3 |
|---|---|
| Entrez Gene | 25542 |
| Alt Symbol | MIP-1a, Scya3 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 3 |
| Other Description | C-C motif chemokine 3|MIP-1-alpha|Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3)|macrophage inflammatory protein 1-alpha|small inducible cytokine A3|small-inducible cytokine A3 |
| Swissprots | A1EC87 P50229 |
| Accessions | EDM05492 P50229 EF121994 ABL63433 EF121995 ABL63434 U06435 AAA96498 U22414 AAA80608 NM_013025 NP_037157 |
| Function | Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. |
| Subcellular Location | Secreted. |
| Top Pathways | Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, Chemokine signaling pathway, Chagas disease (American trypanosomiasis), Rheumatoid arthritis |
CompoZr® Knockout ZFN Kit - CKOZFN51650 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND51650 from Sigma-Aldrich
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CCL3 siRNA (Rat) - CRR0759 from Cohesion Biosciences
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CCL3 - MBS8203901 from MyBioSource
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shRNA set against Rat Ccl3(NM_013025.2) - SHG151143 from Creative biogene
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Rat CCL3 siRNA - orb295608 from Biorbyt
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CCL3 shRNA Plasmid (Rat) - CHR0759 from Cohesion Biosciences
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CCL3 miRNA 3'UTR clone - MiUTR1R-00797 from Creative biogene
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