Clu

Gene Symbol	Clu
Entrez Gene	12759
Alt Symbol	AI893575, ApoJ, Cli, D14Ucla3, SP-40, Sgp-2, Sgp2, Sugp-2
Species	Mouse
Gene Type	protein-coding
Description	clusterin
Other Description	Apolipoprotein J|apo-J|clustrin|complement lysis inhibitor|sulfated glycoprotein 2|testosterone repressed prostate message|testosterone repressed prostate message-2
Swissprots	Q06890
Accessions	AAF06365 EDL01130 Q06890 AF248057 AAF67184 AF248058 AAF67185 AK132030 BAE20954 BC075668 AAH75668 BY248781 CK623407 D14077 BAA03162 L05670 AAA37284 L08235 AAA37422 S70244 AAB30623 XM_006518503 XP_006518566 XM_006518504 XP_006518567 NM_013492 NP_038520
Function	Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promote
Subcellular Location	Secreted {ECO:0000269|PubMed:12551933}. Nucleus {ECO:0000269|PubMed:12551933}. Cytoplasm {ECO:0000269|PubMed:12551933}. Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:12551933}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250}. Note=Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis (By similarity). {ECO:0000250}.
Tissue Specificity	Most abundant in stomach, liver, brain, and testis, with intermediate levels in heart, ovary and kidney.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Clusterin blocking peptide - GTX88520-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Mouse, Rat

Recombinant Mouse Clusterin, CF - 2747-HS-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu22-Arg226 (beta) & Ser227-Glu448 (alpha), with a C-terminal 6-His tag

Mouse CLU His tag protein - orb83954 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Mouse

Mouse Clusterin Protein - abx065949 from Abbexa Category Protein Source E.coli Species Mouse

Apolipoprotein J Peptide - AC21-1705-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Apolipoprotein J Peptide - AC21-2636-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Clusterin (CLU), Mouse - 20-7520 from ARP American Research Products Category Protein Prices $409.00 Sizes 50 µg Source E.coli Species Mouse

Clu Peptide - 42-962P from ProSci Category Peptide Species Mouse, Rat

Clusterin Peptide - 46-749P from ProSci Category Peptide Species Rat

Recombinant Mouse Apoliprotein-J - GWB-777D3A from Genway Biotech Category Protein Prices $75.00, $165.00, $3,230.00 Sizes 5 μg, 20 μg, 1000 μg Species Mouse

Recombinant Mouse Clusterin, Flag-tagged - Clu-1317M from Creative Biomart Category Protein Source Human Embryonic Kidney 293 Cells .

Recombinant Mouse Clusterin - Clu-1867M from Creative Biomart Category Protein Source Human Embryonic Kidney 293 Cells.

Recombinant Mouse Clu, His tagged - Clu-3302M from Creative Biomart Category Protein Source Human Cells Species Mouse

CLU - PN201373 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Mouse

Mouse Clusterin / Apolipoprotein J / Apo-J / CLU Protein (His Tag) - 50485-M08H-50 from Sino Biological Category Protein Source Human Cells Species Mouse

Apo J/Clusterin - PPT-20031 from Nordic BioSite Category Protein Species Mouse

Recombinant Clusterin (CLU) - RPB180Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Clusterin (CLU) - RPB180Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

ApoJ/Clusterin, mouse recombinant - 7554-10 from Biovision Category Protein Prices $225.00 Sizes 10 μg Source E. coli Species Mouse

ApoJ/Clusterin, mouse recombinant - 7554-50 from Biovision Category Protein Prices $735.00 Sizes 50 μg Source E. coli Species Mouse

Recombinant Mouse Clusterin Protein, CF - 2747-HS from R&D Systems Category Protein Prices $329.00, $33,500.00 Sizes 50 µg, 50 µg Source Mouse myeloma cell line, NS0-derived Glu22-Arg226 (beta) & Ser227-Glu448 (alpha), with a C-terminal 6-His tag Species Mouse

Clusterin (CLU) - RPU140847 from Biomatik Category Protein Prices $187.00, $374.00, $561.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Apolipoprotein J / Apo J - TP721223 from Acris Antibodies Category Protein Prices $139.00 Sizes 10 µg Source HEK293 cells Species Mouse

ApoJ/Clusterin, Recombinant Protein - MBS844798 from MyBioSource Category Protein Prices $280.00, $810.00 Sizes 10 µg, 50 µg Source E Coli

Clusterin/ApoJ, Peptide - MBS425526 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Mouse, Rat

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