Clu

Gene Symbol	Clu
Entrez Gene	12759
Alt Symbol	AI893575, ApoJ, Cli, D14Ucla3, SP-40, Sgp-2, Sgp2, Sugp-2
Species	Mouse
Gene Type	protein-coding
Description	clusterin
Other Description	Apolipoprotein J|apo-J|clustrin|complement lysis inhibitor|sulfated glycoprotein 2|testosterone repressed prostate message|testosterone repressed prostate message-2
Swissprots	Q06890
Accessions	AAF06365 EDL01130 Q06890 AF248057 AAF67184 AF248058 AAF67185 AK132030 BAE20954 BC075668 AAH75668 BY248781 CK623407 D14077 BAA03162 L05670 AAA37284 L08235 AAA37422 S70244 AAB30623 XM_006518503 XP_006518566 XM_006518504 XP_006518567 NM_013492 NP_038520
Function	Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promote
Subcellular Location	Secreted {ECO:0000269|PubMed:12551933}. Nucleus {ECO:0000269|PubMed:12551933}. Cytoplasm {ECO:0000269|PubMed:12551933}. Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:12551933}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250}. Note=Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis (By similarity). {ECO:0000250}.
Tissue Specificity	Most abundant in stomach, liver, brain, and testis, with intermediate levels in heart, ovary and kidney.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Clusterin (Apolipoprotein J) Mouse ELISA Kit - ab190543 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity = 1.012 ng/ml Range 1.5 ng/ml - 100 ng/ml

Clusterin (Apolipoprotein J) Mouse SimpleStep ELISA™ Kit - ab199079 from Abcam Category ELISA Kit Prices $470.00 Sizes 1 x 96 tests Sensitivity 0.28 ng/ml Range 0.78 ng/ml - 50 ng/ml

Mouse Clu / Clusterin ELISA Kit - RAB0775 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt

Clusterin ELISA Kit (Mouse) (OKIA00189) - OKIA00189 from Aviva Systems Biology Category ELISA Kit Prices $400.00 Sizes 96 wells Sensitivity 1.012 ng/ml Range 1.56 ng/ml - 100 ng/ml

Clusterin (CLU), Mouse, ELISA Kit - CSB-EL005595MO from ARP American Research Products Category ELISA Kit Prices $325.00, $495.00, $496.00, $498.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Clusterin (CLU), Mouse, ELISA Kit - SEB180Mu from ARP American Research Products Category ELISA Kit Prices $468.00 Sizes 96 t Sensitivity 6.1ng/mL Range 18.8-1,200ng/mL

Clusterin, Clu, Mouse, ELISA Kit - E1180m from ARP American Research Products Category ELISA Kit Prices $496.00 Sizes 96 t Range 1.56-100 ng/ml

Clusterin, Mouse, ELISA Kit - PB-0923 from ARP American Research Products Category ELISA Kit Prices $448.00 Sizes 96 t Sensitivity < 10 pg/ml Range 312pg/ml-20,000pg/ml

Clusterin, Mouse, ELISA Kit - E03C0373 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Range 10-250ng/ml

Custom Mouse Clusterin ELISA - ELM-Clusterin from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Mouse CLU ELISA Kit - MC0380 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse Clusterin ELISA Kit - DEIA2943 from Creative Diagnostics Category ELISA Kit Sensitivity 0.031 ng/mL Range 0.016-0.094 ng/mL

Mouse CLU(Clusterin) ELISA Kit - E-EL-M0303 from Elabscience Category ELISA Kit Sensitivity 1.50 ng/mL Range 2.50—160 ng/mL

Mouse CLU (Clusterin) CLIA Kit - E-CL-M0202 from Elabscience Category CLIA Kit Sensitivity 0.38 ng/mL Range Average Recovery (%)

Clusterin, ELISA Kit - MBS176507 from MyBioSource Category ELISA Kit Prices $455.00 Sizes 1x96 wells Sensitivity < 10pg/ml Range 312pg/ml-20,000pg/ml

Clusterin, ELISA Kit - MBS824963 from MyBioSource Category ELISA Kit Prices $470.00 Sizes 96 tests Sensitivity 10 pg/ml Range 312 pg/ml - 20000 pg/ml

clusterin, ELISA Kit - MBS922524 from MyBioSource Category ELISA Kit Prices $250.00, $650.00, $2,295.00, $4,330.00 Sizes 24 -strip-wells (Limit 1), 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse CLU is typically less than 0.39 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 1.56 ng/ml-100 ng/ml.

SGP-2, Mouse - DP-10151-X from Nordic BioSite

Mouse Clusterin ELISA Kit - CEK1438 from Cohesion Biosciences Category ELISA Kit Prices $360.00 Sizes 96 t Sensitivity 10 pg/ml Range 312 pg/ml - 20000 pg/ml

Mouse Clusterin PicoKine™ ELISA Kit EK0923 - EK0923 from Boster Bio Category ELISA Kit Prices $399.00 Sizes 1 kit Sensitivity <10pg/ml Range 312pg/ml-20,000pg/ml *This assay range is determined using common samples. For samples with low target protein concentrations, users can adjust the standard curve to extend the lower limit of assay range.

Mouse Clusterin(CLU) ELISA kit - CSB-EL005595MO from Cusabio Category ELISA Kit Sensitivity 0.277 ng/ml Range 1.563 ng/ml-100 ng/ml

Mouse Clusterin ELISA - E03C0373 from BlueGene Biotech Category ELISA Kit Sensitivity 1.0 ng/mL

ELISA Kit for Clusterin (CLU) - SEB180Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 7.5ng/mL. Range 18.75-1200ng/mL The standard curve concentrations used for the ELISA's were 1200ng/mL, 600ng/mL, 300ng/mL, 150ng/mL, 75ng/mL, 37.5ng/mL, 18.75ng/mL

Mouse Clusterin (CLU) ELISA Kit - EKU03250 from Biomatik Category ELISA Kit Prices $523.00, $2,405.00, $4,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 7.5 ng/mL Range 18.75-1200 ng/mL

Mouse CLU(Clusterin) ELISA Kit - E-EL-M0303 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 1.5 ng/mL Range 2.5~160 ng/mL

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