| Gene Symbol |
SEMA4A
|
| Entrez Gene |
64218
|
| Alt Symbol |
CORD10, RP35, SEMAB, SEMB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
|
| Other Description |
sema B|semaphorin-4A|semaphorin-B
|
| Swissprots |
Q5TCI5 Q9H3S1 Q8WUA9 B3KR76 Q5TCJ6 B2RDH8
|
| Accessions |
EAW52992 EAW52993 EAW52994 EAW52995 Q9H3S1 AA761091 AB029394 BAB20087 AK022349 BAB14018 AK022416 AK091127 BAG52288 AK290353 BAF83042 AK296693 BAG59287 AK315547 BAG37925 AY358531 AAQ88895 BC020974 AAH20974 BX640891 CAE45942 DA409501 DA508826 DC332598 XM_011509871 XP_011508173 XM_011509872 XP_011508174 XM_011509873 XP_011508175 XM_011509874 XP_011508176 XM_011509875 XP_011508177 XM_011509876 XP_011508178 XM_011509877 XP_011508179 XM_011509878 XP_011508180 XM_011509879 XP_011508181 NM_001193300 NP_001180229 NM_001193301 NP_001180230 NM_001193302 NP_001180231 NM_022367 NP_071762
|
| Function |
Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Top Pathways |
Axon guidance
|