MERTK

Gene Symbol MERTK
Entrez Gene 10461
Alt Symbol MER, RP38, Tyro12, c-Eyk, c-mer
Species Human
Gene Type protein-coding
Description MER proto-oncogene, tyrosine kinase
Other Description MER receptor tyrosine kinase|STK kinase|c-mer proto-oncogene tyrosine kinase|proto-oncogene c-Mer|receptor tyrosine kinase MerTK|tyrosine-protein kinase Mer
Swissprots Q9HBB4 Q12866
Accessions AAK54121 AAX93144 AAY24213 EAW52096 EAW52097 Q12866 AK026681 AK294196 BAG57511 AK308695 AK316584 BAG38172 AL705756 AW627665 BC114917 AAI14918 BC114918 AAI14919 BM719997 BX474860 CA454601 CN371299 CN371300 D16316 BAA03823 U08023 AAB60430 XM_005263565 XP_005263622 XM_005263568 XP_005263625 XM_011510490 XP_011508792 XM_011510491 XP_011508793 NM_006343 NP_006334
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1
Subcellular Location Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

Mer (D21F11) XP ® Rabbit mAb - 4319 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D21F11
Western blot analysis of extracts from SK-MEL-5, Hep G2 and Jurkat cells using Mer (D21F11) XP ® Rabbit mAb.

Mer (348E6) Mouse mAb - 9178 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 348E6
Western blot analysis of U937 cell lysate using Mer (348E6) Mouse mAb.

MerTK (B-1) - sc-365499 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MerTK (B-1): sc-365499. Western blot analysis of MerTK expression in U-937 whole cell lysate.

MerTK (E-20) - sc-66397 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MerTK (E-20): sc-66397. Western blot analysis of human recombinant MerTK fusion protein.

MerTK (C-20) - sc-66395 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MerTK (H-222) - sc-67280 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MerTK (H-222): sc-67280. Western blot analysis of human recombinant MerTK fusion protein.

MerTK (A311) - sc-53985 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

MerTK (M-217) - sc-67281 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MerTK (M-217): sc-67281. Western blot analysis of human recombinant MerTK fusion protein.

MerTK (348) - sc-53984 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

MerTK (N-20) - sc-66400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MER + SKY antibody - ab79223 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Left panel: immunohistochemistry analysis of paraffin-embedded Human brain tissue using 1/50 ab79223. Right panel: same, after pre-incubation with the immunizing peptide.

Anti-MERTK (phospho Y681 + Y749) antibody - ab192649 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MERTK (phospho Y681 + Y749) antibody (ab192649) at 1/500 dilutionLane 1 : 3T3 cell extract treated with EGFLane 2 : 3T3 cell extract treated with EGF with antigen-specific peptide

Anti-MERTK (phospho Y749 + Y753 + Y754) antibody - ab14921 from Abcam

Prices $372.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MERTK antibody - ab14919 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MERTK antibody - ab196880 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MERTK antibody (ab196880) at 1/500 dilutionLane 1 : 3T3 cell extracts with blocking peptideLane 2 : 3T3 cell extracts

Anti-MERTK antibody - ab37834 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MERTK antibody (ab37834) at 1/100 dilution + Mouse NIH/3T3 cell lysate.

Anti-MERTK antibody - ab70693 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MERTK antibody (ab70693) at 0.1 µg/ml + U937 cell lysate at 50 µg

Anti-MERTK antibody - ab14920 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MERTK antibody - ab110108 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab110108 at 3.75 µg/ml staining MERTK in Formalin-Fixed, Paraffin-Embedded Human Adrenal tissue.

Anti-MERTK antibody - ab188117 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-MERTK antibody (ab188117) at 2 µg/ml + Daudi cell lysate at 35 µg

Anti-MERTK antibody [A311F9G3] - ab52591 from Abcam

Prices $382.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone A311F9G3
Overlay histogram showing HEK293 cells stained with ab52591 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab52591, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-MERTK antibody [Y323] - ab52968 from Abcam

Prices $392.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y323
All lanes : Anti-MERTK antibody [Y323] (ab52968) at 1/2000 dilution (purified)Lane 1 : HEK293 cell lysateLane 2 : K562 cell lysateLysates/proteins at 20 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG at 1/1000 dilutionObserved band size : 140-180 kDa (why is the actual band size different from the predicted?)Blocking buffer and concentration: 5% NFDM/TBST.Diluting buffer and concentration: 5% NFDM /TBST.

Anti-MER / MERTK Antibody (aa200-250) - LS-C72435 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MER / MERTK Antibody (aa746-757) - LS-C72438 from LifeSpan Bioscience

Prices $710.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MER / MERTK Antibody (Extracellular Domain) - LS-C125930 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
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