MERTK

Gene Symbol	MERTK
Entrez Gene	10461
Alt Symbol	MER, RP38, Tyro12, c-Eyk, c-mer
Species	Human
Gene Type	protein-coding
Description	MER proto-oncogene, tyrosine kinase
Other Description	MER receptor tyrosine kinase|STK kinase|c-mer proto-oncogene tyrosine kinase|proto-oncogene c-Mer|receptor tyrosine kinase MerTK|tyrosine-protein kinase Mer
Swissprots	Q9HBB4 Q12866
Accessions	AAK54121 AAX93144 AAY24213 EAW52096 EAW52097 Q12866 AK026681 AK294196 BAG57511 AK308695 AK316584 BAG38172 AL705756 AW627665 BC114917 AAI14918 BC114918 AAI14919 BM719997 BX474860 CA454601 CN371299 CN371300 D16316 BAA03823 U08023 AAB60430 XM_005263565 XP_005263622 XM_005263568 XP_005263625 XM_011510490 XP_011508792 XM_011510491 XP_011508793 NM_006343 NP_006334
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MERTK (mutated A708 S) protein fragment - ab167957 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human MERTK protein fragment - ab72490 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human MERTK protein fragment - ab161003 from Abcam Category Protein Source Wheat germ Species Human

MERTK peptide - ab106208 from Abcam Category Peptide

MER / MERTK Antibody Blocking Peptide - LS-E25536 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MER / MERTK Blocking Peptide - LS-E9163 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Mer Partial Recombinant Protein - H00010461-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Mer Peptide - P2698 from Novus Biologicals Category Peptide Species Human

MERTK-Antibody-N-term-Blocking-peptide - BP7662a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MERTK blocking peptide - GTX89814-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human Mer Fc Chimera, CF - 891-MR-100 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Human c MER protein - orb83076 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

Human MERTK protein - orb139334 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Baculovirus-Insect Cells Species Human

Human MERTK protein GST Tag - orb139332 from Biorbyt Category Protein Prices $570.00, $663.00 Sizes 20 μg, 50 μg Source Baculovirus-Insect Cells Species Human

Human MERTK protein - orb232223 from Biorbyt Category Protein Prices $238.00, $434.00 Sizes 20 μg, 100 μg Species Human

Mouse c MER protein - orb84627 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 100 μg, 200 μg Source Mouse Species Human

MERTK Blocking Peptide - abx063678 from Abbexa Category Peptide Species Human, Mouse, Rat

MERTK Blocking Peptide - abx063679 from Abbexa Category Peptide Species Human

MERTK Peptide - AC21-0365-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MERTK - H00010461-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MERTK - H00010461-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MERTK - P5596 from Acris Antibodies Category Protein Prices $1,180.00 Sizes 5 µg Species Human

MERTK Control Peptide - AP10149CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

MERTK Control Peptide - AP10150CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

MERTK control peptide - AP10151CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

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