Gene Symbol | CTNNA3 |
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Entrez Gene | 29119 |
Alt Symbol | ARVD13, VR22 |
Species | Human |
Gene Type | protein-coding |
Description | catenin (cadherin-associated protein), alpha 3 |
Other Description | alpha-T-catenin|alpha-catenin-like protein|catenin alpha-3 |
Swissprots | Q5VSR2 Q9UI47 Q6P056 |
Accessions | AAQ14328 CCQ43416 EAW54249 EAW54250 EAW54251 Q9UI47 AF091606 AAF21801 AK289756 BAF82445 AK308726 AK313882 BAG36608 AY198183 AAO43101 BC022004 AAH22004 BC030646 AAH30646 BC065819 AAH65819 BP362015 BX103986 XM_005269717 XP_005269774 XM_011539721 XP_011538023 XM_011539722 XP_011538024 XM_011539723 XP_011538025 XM_011539724 XP_011538026 XM_011539725 XP_011538027 XM_011539726 XP_011538028 XM_011539727 XP_011538029 NM_001127384 NP_001120856 NM_001291133 NP_001278062 NM_013266 NP_037398 |
Function | May be involved in formation of stretch-resistant cell- cell adhesion complexes. {ECO:0000303|PubMed:11590244}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000305}. Note=Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. {ECO:0000269|PubMed:11590244}. |
Tissue Specificity | Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle. {ECO:0000269|PubMed:11590244}. |
Top Pathways | Adherens junction, Tight junction, Leukocyte transendothelial migration, Endometrial cancer, Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
α T-catenin CRISPR/Cas9 KO Plasmid (h) - sc-407489 from Santa Cruz Biotechnology
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α T-catenin HDR Plasmid (h) - sc-407489-HDR from Santa Cruz Biotechnology
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α T-catenin Double Nickase Plasmid (h) - sc-407489-NIC from Santa Cruz Biotechnology
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α T-catenin Double Nickase Plasmid (h2) - sc-407489-NIC-2 from Santa Cruz Biotechnology
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α T-catenin CRISPR Activation Plasmid (h) - sc-407489-ACT from Santa Cruz Biotechnology
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α T-catenin CRISPR Activation Plasmid (h2) - sc-407489-ACT-2 from Santa Cruz Biotechnology
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α T-catenin Lentiviral Activation Particles (h) - sc-407489-LAC from Santa Cruz Biotechnology
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α T-catenin Lentiviral Activation Particles (h2) - sc-407489-LAC-2 from Santa Cruz Biotechnology
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α T-catenin siRNA (h) - sc-61904 from Santa Cruz Biotechnology
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α T-catenin shRNA Plasmid (h) - sc-61904-SH from Santa Cruz Biotechnology
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α T-catenin shRNA (h) Lentiviral Particles - sc-61904-V from Santa Cruz Biotechnology
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CTNNA3 RNAi - H00029119-R01 from Novus Biologicals
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MISSION® esiRNA - EHU061051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6735 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6735 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00304 from Sigma-Aldrich
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CTNNA3 siRNA (Human) - CRH9208 from Cohesion Biosciences
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CTNNA3 - MBS8213998 from MyBioSource
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shRNA set against Human CTNNA3 (NM_013266.2) - SHH271285 from Creative biogene
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Human CTNNA3 siRNA - orb269710 from Biorbyt
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CTNNA3 shRNA Plasmid (Human) - CHH9208 from Cohesion Biosciences
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CTNNA3 miRNA 3'UTR clone - MiUTR3H-09375 from Creative biogene
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CTNNA3 miRNA 3'UTR clone - MiUTR3H-09376 from Creative biogene
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