| Gene Symbol |
SET
|
| Entrez Gene |
6418
|
| Alt Symbol |
2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SET nuclear proto-oncogene
|
| Other Description |
HLA-DR-associated protein II|SET nuclear oncogene|SET translocation (myeloid leukemia-associated)|Template-Activating Factor-I, chromatin remodelling factor|inhibitor of granzyme A-activated DNase|inhibitor-2 of protein phosphatase-2A|phosphatase 2A inhibitor I2PP2A|protein SET|protein phosphatase type 2A inhibitor
|
| Swissprots |
B4DUE2 Q5VXV1 A6NGV1 Q5VXV2 Q15541 Q01105 Q6FHZ5 A5A5H4
|
| Accessions |
EAW87818 EAW87819 EAW87820 EAW87821 EAW87822 EAW87823 Q01105 AK223556 BAD97276 AK300609 BAG62304 AK300794 BAG62453 AK311346 AK315313 BAG37717 AM392720 CAL37598 AM392742 CAL37620 AM393022 CAL37900 AM393175 CAL38053 AM393446 CAL38324 AY349172 AAQ79833 BC014567 BC032749 AAH32749 BP343325 BQ774097 BU543146 CA392072 CA419540 CB129868 CN408133 CR536543 CAG38780 CR542050 CAG46847 D45198 BAA08139 DQ894408 ABM85334 EF534308 ABP96841 EU176263 ABW03714 JF729356 AEO27880 M93651 AAA60318 U51924 AAC50460 X75091 CAA52982 XM_011518911 XP_011517213 NM_001122821 NP_001116293 NM_001248000 NP_001234929 NM_001248001 NP_001234930 NM_003011 NP_003002
|
| Function |
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T- lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. {ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:12628186}.
|
| Subcellular Location |
Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium.
|
| Tissue Specificity |
Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or differentiation. Highly expressed in Wilms' tumor.
|