PLAT

Gene Symbol PLAT
Entrez Gene 281407
Alt Symbol -
Species Bovine
Gene Type protein-coding
Description plasminogen activator, tissue
Other Description t-PA|t-plasminogen activator|tPA|tissue plasminogen activator|tissue-type plasminogen activator
Swissprots Q2KJG9 Q28198
Accessions AAF79125 DAA14425 Q28198 BC105348 AAI05349 X85800 CAA59795 NM_174146 NP_776571
Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
Subcellular Location Secreted, extracellular space.
Top Pathways Complement and coagulation cascades, Transcriptional misregulation in cancer

Anti-TPA Tissue Plasminogen Activator antibody - ab47033 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab47033 stained A431 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab47033, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.
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