| Gene Symbol |
PLAT
|
| Entrez Gene |
281407
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
plasminogen activator, tissue
|
| Other Description |
t-PA|t-plasminogen activator|tPA|tissue plasminogen activator|tissue-type plasminogen activator
|
| Swissprots |
Q2KJG9 Q28198
|
| Accessions |
AAF79125 DAA14425 Q28198 BC105348 AAI05349 X85800 CAA59795 NM_174146 NP_776571
|
| Function |
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
|
| Subcellular Location |
Secreted, extracellular space.
|
| Top Pathways |
Complement and coagulation cascades, Transcriptional misregulation in cancer
|