Gene Symbol | PLA2G4D |
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Entrez Gene | 283748 |
Alt Symbol | cPLA2delta |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase A2, group IVD (cytosolic) |
Other Description | cPLA2-delta|cytosolic phospholipase A2 delta|phospholipase A2 delta, cytosolic|phospholipase A2 group IVD |
Swissprots | Q86XP0 Q8N176 |
Accessions | EAW92529 EAW92530 Q86XP0 AB090876 BAC67158 BC034571 AAH34571 BC140416 AAI40417 BC146533 AAI46534 DQ891792 ABM82718 DQ894974 ABM85900 XM_011521467 XP_011519769 XR_931798 NM_178034 NP_828848 |
Function | Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions. {ECO:0000269|PubMed:14709560}. |
Subcellular Location | Cytoplasm, cytosol. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin. {ECO:0000269|PubMed:14709560}. |
Top Pathways | Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels |
group IVD sPLA 2 (H-105) - sc-368567 from Santa Cruz Biotechnology
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group IVD sPLA 2 (N-20) - sc-160396 from Santa Cruz Biotechnology
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group IVD sPLA 2 (T-13) - sc-160399 from Santa Cruz Biotechnology
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Anti-PLA2G4D antibody - ab111126 from Abcam
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Anti-PLA2G4D antibody - ab69368 from Abcam
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Anti-PLA2G4D antibody - ab173395 from Abcam
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Anti-PLA2G4D Antibody (aa531-580) - LS-C119894 from LifeSpan Bioscience
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PLA2G4D Antibody - NBP1-85481 from Novus Biologicals
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PLA2G4D Antibody - H00283748-D01P from Novus Biologicals
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PLA2G4D Antibody - H00283748-B01 from Novus Biologicals
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PLA2G4D Antibody - H00283748-B01P from Novus Biologicals
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Anti-PLA2G4D antibody produced in mouse - SAB1402080 from Sigma-Aldrich
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Anti-PLA2G4D antibody produced in rabbit - SAB1402081 from Sigma-Aldrich
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Anti-PLA2G4D antibody produced in rabbit - HPA039489 from Sigma-Aldrich
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PLA2G4D Antibody (OAAF03554) - OAAF03554 from Aviva Systems Biology
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PLA2G4D antibody - 70R-19325 from Fitzgerald
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PLA2G4D antibody - 70R-36388 from Fitzgerald
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PLA2G4D antibody - 13345-1-AP from Acris Antibodies
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PLA2G4D antibody - H00283748-B01 from Acris Antibodies
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PLA2G4D antibody - H00283748-B01P from Acris Antibodies
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PLA2G4D antibody - H00283748-D01P from Acris Antibodies
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Anti-cPLA2-δ antibody - STJ92451 from St John's Laboratory Ltd
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PLA2G4D antibody - 13345-1-AP from Proteintech Group
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PLA2G4D Polyclonal Antibody - PA002995-C15306 from Syd Labs
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PLA2G4D Antibody - E11-15306C from Enogene
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