| Gene Symbol | PLA2G4D |
|---|---|
| Entrez Gene | 283748 |
| Alt Symbol | cPLA2delta |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipase A2, group IVD (cytosolic) |
| Other Description | cPLA2-delta|cytosolic phospholipase A2 delta|phospholipase A2 delta, cytosolic|phospholipase A2 group IVD |
| Swissprots | Q86XP0 Q8N176 |
| Accessions | EAW92529 EAW92530 Q86XP0 AB090876 BAC67158 BC034571 AAH34571 BC140416 AAI40417 BC146533 AAI46534 DQ891792 ABM82718 DQ894974 ABM85900 XM_011521467 XP_011519769 XR_931798 NM_178034 NP_828848 |
| Function | Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions. {ECO:0000269|PubMed:14709560}. |
| Subcellular Location | Cytoplasm, cytosol. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin. {ECO:0000269|PubMed:14709560}. |
| Top Pathways | Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, VEGF signaling pathway, Inflammatory mediator regulation of TRP channels |
group IVD sPLA 2 CRISPR/Cas9 KO Plasmid (h) - sc-415332 from Santa Cruz Biotechnology
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group IVD sPLA 2 HDR Plasmid (h) - sc-415332-HDR from Santa Cruz Biotechnology
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group IVD sPLA 2 Double Nickase Plasmid (h) - sc-415332-NIC from Santa Cruz Biotechnology
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group IVD sPLA 2 Double Nickase Plasmid (h2) - sc-415332-NIC-2 from Santa Cruz Biotechnology
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group IVD sPLA 2 CRISPR Activation Plasmid (h) - sc-415332-ACT from Santa Cruz Biotechnology
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group IVD sPLA 2 CRISPR Activation Plasmid (h2) - sc-415332-ACT-2 from Santa Cruz Biotechnology
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group IVD sPLA 2 Lentiviral Activation Particles (h) - sc-415332-LAC from Santa Cruz Biotechnology
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group IVD sPLA 2 Lentiviral Activation Particles (h2) - sc-415332-LAC-2 from Santa Cruz Biotechnology
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group IVD sPLA 2 siRNA (h) - sc-90240 from Santa Cruz Biotechnology
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group IVD sPLA 2 shRNA Plasmid (h) - sc-90240-SH from Santa Cruz Biotechnology
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group IVD sPLA 2 shRNA (h) Lentiviral Particles - sc-90240-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU031441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16897 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16897 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08085 from Sigma-Aldrich
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PLA2G4D siRNA (Human) - CRJ6933 from Cohesion Biosciences
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shRNA set against Human PLA2G4D (NM_178034.3) - SHH376844 from Creative biogene
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shRNA set against Human PLA2G4D(NM_178034.3) - SHR119190 from Creative biogene
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PLA2G4D shRNA Plasmid (Human) - CHJ6933 from Cohesion Biosciences
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PLA2G4D miRNA 3'UTR clone - MiUTR1H-07962 from Creative biogene
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