| Gene Symbol | PTPRU |
|---|---|
| Entrez Gene | 10076 |
| Alt Symbol | FMI, PCP-2, PTP, PTP-J, PTP-PI, PTP-RO, PTPPSI, PTPRO, PTPU2, R-PTP-PSI, R-PTP-U, hPTP-J |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, receptor type, U |
| Other Description | PTP pi|Receptor protein tyrosine phosphatase hPTP-J|pancreatic carcinoma phosphatase 2|pi R-PTP-Psi|protein-tyrosine phosphatase J|protein-tyrosine phosphatase pi|protein-tyrosine phosphatase receptor omicron|receptor-type protein-tyrosine phosphatase psi|receptor-type tyrosine-protein phosphatase U |
| Swissprots | Q5SYU4 Q92850 Q5SYU5 Q92729 Q92735 A6H8L1 O00197 P78399 Q59HA4 |
| Accessions | AAB07074 CCQ43332 EAX07650 EAX07651 EAX07652 Q92729 AB208855 BAD92092 AK094849 BAG52941 BC033131 BC146655 AAI46656 BM799833 BU687539 CN410555 U71075 AAC51938 U73727 AAB51343 X95712 CAA65016 X97198 CAA65832 XM_006710269 XP_006710332 XM_006710270 XP_006710333 XM_006710272 XP_006710335 XM_006710273 XP_006710336 XM_011540458 XP_011538760 NM_001195001 NP_001181930 NM_005704 NP_005695 NM_133177 NP_573438 NM_133178 NP_573439 |
| Function | Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12501215, ECO:0000269|PubMed:16574648}. |
| Subcellular Location | Cell junction {ECO:0000269|PubMed:8700514}. Cell membrane {ECO:0000269|PubMed:8700514}; Single-pass type I membrane protein {ECO:0000269|PubMed:8700514}. |
| Tissue Specificity | High levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach, and uterus; not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells. {ECO:0000269|PubMed:8700514, ECO:0000269|PubMed:8870675, ECO:0000269|PubMed:9070223, ECO:0000269|PubMed:9434160}. |