| Gene Symbol |
Notch2
|
| Entrez Gene |
18129
|
| Alt Symbol |
AI853703, N2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
notch 2
|
| Other Description |
Motch B|Notch gene homolog 2|neurogenic locus notch homolog protein 2
|
| Swissprots |
Q06008 Q60941 O35516
|
| Accessions |
EDL38950 EDL38951 O35516 AK027963 AK155137 BAE33071 AK155666 BAE33376 AK157200 BC059256 AAH59256 BC172642 AAI72642 D32210 BAA22094 U31881 AAC52924 X68279 CAA48340 NM_010928 NP_035058
|
| Function |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. {ECO:0000250, ECO:0000269|PubMed:10393120, ECO:0000269|PubMed:18710934}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in the brain, liver, kidney, neuroepithelia, somites, optic vesicles and branchial arches, but not heart.
|
| Top Pathways |
Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation
|