Notch2

Gene Symbol Notch2
Entrez Gene 18129
Alt Symbol AI853703, N2
Species Mouse
Gene Type protein-coding
Description notch 2
Other Description Motch B|Notch gene homolog 2|neurogenic locus notch homolog protein 2
Swissprots Q06008 Q60941 O35516
Accessions EDL38950 EDL38951 O35516 AK027963 AK155137 BAE33071 AK155666 BAE33376 AK157200 BC059256 AAH59256 BC172642 AAI72642 D32210 BAA22094 U31881 AAC52924 X68279 CAA48340 NM_010928 NP_035058
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. {ECO:0000250, ECO:0000269|PubMed:10393120, ECO:0000269|PubMed:18710934}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in the brain, liver, kidney, neuroepithelia, somites, optic vesicles and branchial arches, but not heart.
Top Pathways Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

Recombinant Mouse Notch-2 Fc Chimera, CF - 5196-NT-050 from R&D Systems

Category Protein
Source Chinese Hamster Ovary cell line, CHO-derived

Recombinant Mouse Notch2, Fc-tagged - Notch2-436M from Creative Biomart

Category Protein
Source CHO Cells
Species Mouse

Recombinant Mouse Notch2, Fc Chimera - Notch2-650M from Creative Biomart

Category Protein
Source CHO Cells
Species Mouse

Recombinant Mouse Neurogenic locus notch homolog protein 2(Notch2) ,partial - CSB-YP015950MO CSB-EP015950MO CSB-BP015950MO CSB-MP015950MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Notch-2, mouse recombinant - 7531-25 from Biovision

Category Protein
Prices $225.00
Sizes 25 μg
Source CHO cells
Species Mouse

Recombinant Mouse Notch-2 Fc Chimera Protein, CF - 5196-NT from R&D Systems

Category Protein
Prices $329.00
Sizes 50 µg
Source Chinese Hamster Ovary cell line, CHO-derived Mouse Notch-2 (Leu26 - Val528) Accession #NP_035058 IEGRMDP Mouse IgG 2a (Glu98 - Lys330) N-terminus C-terminus
Species Mouse

Notch-2, mouse recombinant - 7531 from Biovision

Category Protein
Prices $235.00
Sizes 25 μg
Source CHO cells
Species Mouse

Notch2 Recombinant Protein - 90-292 from ProSci

Category Protein
Prices $375.00
Sizes 50 µg
Source CHO cells
Species Mouse

Notch-2, Mouse recombinant - 268-11120-1 from RayBiotech

Category Protein
Species Mouse

Neurogenic locus notch homolog protein 2 (Notch2), partial, Recombinant Protein - MBS1025822 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Notch-2, Recombinant Protein - MBS844650 from MyBioSource

Category Protein
Prices $280.00
Sizes 25 µg
Source CHO Cells
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