| Gene Symbol |
VASH1
|
| Entrez Gene |
22846
|
| Alt Symbol |
KIAA1036
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vasohibin 1
|
| Other Description |
vasohibin-1
|
| Swissprots |
Q9UBF4 Q7L8A9 Q96H02 Q9Y629
|
| Accessions |
AAD44361 AAF02829 EAW81259 EAW81260 Q7L8A9 AB028959 BAA82988 AF055021 AK094330 AK291377 BAF84066 AL041425 AL832588 CAD89941 BC009031 AAH09031 BC051896 AAH51896 BE674799 BF741850 XM_006720080 XP_006720143 XM_011536556 XP_011534858 XM_011536557 XP_011534859 XM_011536558 XP_011534860 XM_011536559 XP_011534861 XM_011536560 XP_011534862 XM_011536561 XP_011534863 XM_011536562 XP_011534864 NM_014909 NP_055724
|
| Function |
Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity. {ECO:0000269|PubMed:15467828, ECO:0000269|PubMed:16488400, ECO:0000269|PubMed:16707096}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:15467828, ECO:0000269|PubMed:16707096}.
|
| Tissue Specificity |
Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions. {ECO:0000269|PubMed:15467828, ECO:0000269|PubMed:16707096}.
|
