PEAK1
| Gene Symbol | PEAK1 |
|---|---|
| Entrez Gene | 79834 |
| Alt Symbol | SGK269 |
| Species | Human |
| Gene Type | protein-coding |
| Description | pseudopodium-enriched atypical kinase 1 |
| Other Description | NKF3 kinase family member|sugen kinase 269|tyrosine-protein kinase SgK269 |
| Swissprots | Q8NAZ4 Q6ZS78 Q8TEG7 Q8NCM3 Q9H792 |
| Accessions | Q9H792 AB082533 BAC02711 AF086416 AF088077 AK024793 BAB15006 AK025943 AK074157 BAB84983 AK091802 AK124548 AK127658 BAC87076 AW069191 BC172320 AAI72320 BX953442 DA651665 XM_005254670 XP_005254727 XM_005254671 XP_005254728 XM_005254673 XP_005254730 XM_005254674 XP_005254731 XM_005254675 XP_005254732 XM_011522033 XP_011520335 XM_011522034 XP_011520336 XM_011522035 XP_011520337 XM_011522036 XP_011520338 XM_011522037 XP_011520339 XM_011522038 XP_011520340 XM_011522039 XP_011520341 XM_011522040 XP_011520342 XM_011522041 XP_011520343 XM_011522042 XP_011520344 NM_024776 NP_079052 |
| Function | Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN. {ECO:0000269|PubMed:20534451}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20534451}. Cell junction, focal adhesion {ECO:0000269|PubMed:20534451}. Note=Colocalizes with F-actin in serum-rich medium. Actin colocalization is reduced during serum starvation. |
SgK269 CRISPR/Cas9 KO Plasmid (h) - sc-403322 from Santa Cruz Biotechnology
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SgK269 HDR Plasmid (h) - sc-403322-HDR from Santa Cruz Biotechnology
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SgK269 Double Nickase Plasmid (h) - sc-403322-NIC from Santa Cruz Biotechnology
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SgK269 Double Nickase Plasmid (h2) - sc-403322-NIC-2 from Santa Cruz Biotechnology
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SgK269 CRISPR Activation Plasmid (h) - sc-403322-ACT from Santa Cruz Biotechnology
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SgK269 CRISPR Activation Plasmid (h2) - sc-403322-ACT-2 from Santa Cruz Biotechnology
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SgK269 Lentiviral Activation Particles (h) - sc-403322-LAC from Santa Cruz Biotechnology
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SgK269 Lentiviral Activation Particles (h2) - sc-403322-LAC-2 from Santa Cruz Biotechnology
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SgK269 siRNA (h) - sc-90265 from Santa Cruz Biotechnology
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SgK269 shRNA Plasmid (h) - sc-90265-SH from Santa Cruz Biotechnology
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SgK269 shRNA (h) Lentiviral Particles - sc-90265-V from Santa Cruz Biotechnology
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PEAK1 RNAi - H00079834-R02 from Novus Biologicals
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MISSION® esiRNA - EHU049151 from Sigma-Aldrich
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MISSION® siRNA - SIHK2065 from Sigma-Aldrich
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MISSION® siRNA - SIHK2068 from Sigma-Aldrich
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MISSION® siRNA - SIHK2064 from Sigma-Aldrich
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MISSION® siRNA - SIHK2071 from Sigma-Aldrich
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MISSION® siRNA - SIHK2069 from Sigma-Aldrich
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MISSION® siRNA - SIHK2067 from Sigma-Aldrich
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MISSION® siRNA - SIHK2070 from Sigma-Aldrich
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MISSION® siRNA - SIHK2072 from Sigma-Aldrich
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MISSION® siRNA - SIHK2066 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16603 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16603 from Sigma-Aldrich
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PEAK1 siRNA (Human) - CRJ2599 from Cohesion Biosciences
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