| Gene Symbol |
ADGRE2
|
| Entrez Gene |
30817
|
| Alt Symbol |
CD312, EMR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adhesion G protein-coupled receptor E2
|
| Other Description |
EGF-like module-containing mucin-like hormone receptor-like 2|egf-like module containing, mucin-like, hormone receptor-like 2
|
| Swissprots |
E9PFQ5 E9PEL6 B4DQ96 E7ESD7 Q9Y4B1 E9PBR1 Q8NG96 Q9UHX3 E9PG91
|
| Accessions |
AAC05172 AAC27673 BAC06146 EAW84445 EAW84446 EAW84447 EAW84448 Q9UHX3 AF114491 AAF21974 AK024426 BAB15716 AK024454 BAB15744 AK222891 BAD96611 AK291776 BAF84465 AK298690 BAG60850 AK298700 BAG60858 AK301458 BAG62980 BC034949 AAH34949 BC053933 AAH53933 BC082991 BC127004 AAI27005 BC127005 AAI27006 BG720310 BG721006 CN480316 CR936819 XM_011527948 XP_011526250 XM_011527949 XP_011526251 XM_011527950 XP_011526252 XM_011527951 XP_011526253 XM_011527952 XP_011526254 XM_011527953 XP_011526255 XM_011527954 XP_011526256 XM_011527955 XP_011526257 XR_936171 XR_936172 XR_936173 XR_936174 NM_001271052 NP_001257981 NM_013447 NP_038475 NM_152916 NM_152917 NM_152918 NM_152919 NM_152920 NM_152921
|
| Function |
Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. {ECO:0000269|PubMed:12829604, ECO:0000269|PubMed:17928360, ECO:0000269|PubMed:22310662}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells.
|
| Tissue Specificity |
Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. {ECO:0000269|PubMed:10903844, ECO:0000269|PubMed:11994511}.
|
