| Gene Symbol | Chst3 |
|---|---|
| Entrez Gene | 53374 |
| Alt Symbol | C6ST, C6ST-1, GST-0 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | carbohydrate (chondroitin 6/keratan) sulfotransferase 3 |
| Other Description | carbohydrate sulfotransferase 3|chondroitin 6-O-sulfotransferase 1|chondroitin 6-sulfotransferase|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0 |
| Swissprots | Q794I5 O88199 |
| Accessions | BAB72166 EDL32179 EDL32180 O88199 AB008937 BAA29054 AB008938 BAA29055 AK134391 BC055055 AAH55055 BP757294 CJ142827 XM_011243510 XP_011241812 XM_011243511 XP_011241813 XM_011243512 XP_011241814 XM_011243513 XP_011241815 NM_016803 NP_058083 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N- acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. {ECO:0000269|PubMed:11696535, ECO:0000269|PubMed:9597547}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Highly expressed in spleen, lung, eye and stomach. Constitutively expressed at low level during the mid- to late-gestation period. Expressed in the brain in a temporally controlled manner: peaks at 2 weeks after birth in the cerebellum, but at 3 weeks in the cerebrum. Localizes to stromal cells in the bone marrow, and stromal cells in the marginal zone and red pulp of the spleen, but the sense probe did not. {ECO:0000269|PubMed:9597547}. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
C6ST-1 CRISPR/Cas9 KO Plasmid (m) - sc-424698 from Santa Cruz Biotechnology
|
||||||||
C6ST-1 HDR Plasmid (m) - sc-424698-HDR from Santa Cruz Biotechnology
|
||||||||
C6ST-1 Double Nickase Plasmid (m) - sc-424698-NIC from Santa Cruz Biotechnology
|
||||||||
C6ST-1 Double Nickase Plasmid (m2) - sc-424698-NIC-2 from Santa Cruz Biotechnology
|
||||||||
C6ST-1 CRISPR Activation Plasmid (m) - sc-424698-ACT from Santa Cruz Biotechnology
|
||||||||
C6ST-1 CRISPR Activation Plasmid (m2) - sc-424698-ACT-2 from Santa Cruz Biotechnology
|
||||||||
C6ST-1 Lentiviral Activation Particles (m) - sc-424698-LAC from Santa Cruz Biotechnology
|
||||||||
C6ST-1 Lentiviral Activation Particles (m2) - sc-424698-LAC-2 from Santa Cruz Biotechnology
|
||||||||
C6ST-1 siRNA (m) - sc-60306 from Santa Cruz Biotechnology
|
||||||||
C6ST-1 shRNA Plasmid (m) - sc-60306-SH from Santa Cruz Biotechnology
|
||||||||
C6ST-1 shRNA (m) Lentiviral Particles - sc-60306-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN28748 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28748 from Sigma-Aldrich
|
||||||||
CHST3 siRNA (Mouse) - CRM5355 from Cohesion Biosciences
|
||||||||
CHST3 - MBS8213968 from MyBioSource
|
||||||||
shRNA set against Mouse CHST3 (NM_016803.3) - SHH263808 from Creative biogene
|
||||||||
Mouse CHST3 siRNA - orb284831 from Biorbyt
|
||||||||
CHST3 shRNA Plasmid (Mouse) - CHM5355 from Cohesion Biosciences
|
||||||||