| Gene Symbol |
IGFBPL1
|
| Entrez Gene |
347252
|
| Alt Symbol |
IGFBP-RP4, IGFBPRP4, bA113O24.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
insulin-like growth factor binding protein-like 1
|
| Other Description |
IGFBP-related protein 10|insulin-like growth factor binding protein related protein 4|insulin-like growth factor-binding protein-like 1|insulin-like growth factor-binding-related protein 4
|
| Swissprots |
Q8WX77
|
| Accessions |
EAW58251 Q8WX77 AK055716 AK131521 BC146371 AAI46372 NM_001007563 NP_001007564
|
| Function |
IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein. {ECO:0000250, ECO:0000269|PubMed:15845387}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:15845387}.
|
| Tissue Specificity |
Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung. {ECO:0000269|PubMed:15845387}.
|