| Gene Symbol | CNOT2 |
|---|---|
| Entrez Gene | 4848 |
| Alt Symbol | CDC36, HSPC131, NOT2, NOT2H |
| Species | Human |
| Gene Type | protein-coding |
| Description | CCR4-NOT transcription complex, subunit 2 |
| Other Description | CCR4-NOT transcription complex subunit 2|CCR4-associated factor 2|negative regulator of transcription 2 |
| Swissprots | Q9NSX5 Q9P028 Q9NWR6 Q9H3E0 Q9NZN8 |
| Accessions | EAW97245 EAW97246 EAW97247 EAW97248 EAW97249 Q9NZN8 AA234384 AF044215 AAQ13426 AF113226 AAG39297 AF161480 AAF29095 AF180473 AAF29827 AK000662 BAA91313 AK095789 BAG53128 AK129966 BAC85263 AK307479 AK315715 BAG38074 AL137674 CAB70869 AY395696 AAR32245 BC002597 AAH02597 BC011826 AAH11826 BX641116 CAE46054 DA445519 DB038192 EU446948 ABZ92477 XM_006719429 XP_006719492 XM_006719430 XP_006719493 XM_006719432 XP_006719495 XM_006719433 XP_006719496 XM_011538399 XP_011536701 XM_011538400 XP_011536702 XM_011538401 XP_011536703 NM_001199302 NP_001186231 NM_001199303 NP_001186232 NM_014515 NP_055330 NR_037615 |
| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21299754}. Nucleus {ECO:0000305|PubMed:21299754}. |
| Tissue Specificity | Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:10637334}. |
| Top Pathways | RNA degradation |