CNOT2

Gene Symbol CNOT2
Entrez Gene 4848
Alt Symbol CDC36, HSPC131, NOT2, NOT2H
Species Human
Gene Type protein-coding
Description CCR4-NOT transcription complex, subunit 2
Other Description CCR4-NOT transcription complex subunit 2|CCR4-associated factor 2|negative regulator of transcription 2
Swissprots Q9NSX5 Q9P028 Q9NWR6 Q9H3E0 Q9NZN8
Accessions EAW97245 EAW97246 EAW97247 EAW97248 EAW97249 Q9NZN8 AA234384 AF044215 AAQ13426 AF113226 AAG39297 AF161480 AAF29095 AF180473 AAF29827 AK000662 BAA91313 AK095789 BAG53128 AK129966 BAC85263 AK307479 AK315715 BAG38074 AL137674 CAB70869 AY395696 AAR32245 BC002597 AAH02597 BC011826 AAH11826 BX641116 CAE46054 DA445519 DB038192 EU446948 ABZ92477 XM_006719429 XP_006719492 XM_006719430 XP_006719493 XM_006719432 XP_006719495 XM_006719433 XP_006719496 XM_011538399 XP_011536701 XM_011538400 XP_011536702 XM_011538401 XP_011536703 NM_001199302 NP_001186231 NM_001199303 NP_001186232 NM_014515 NP_055330 NR_037615
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21299754}. Nucleus {ECO:0000305|PubMed:21299754}.
Tissue Specificity Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:10637334}.
Top Pathways RNA degradation

Human CNOT2 full length protein - ab159006 from Abcam

Category Protein
Source Wheat germ
Species Human
ab159006 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human CNOT2 protein fragment - ab159007 from Abcam

Category Protein
Source Wheat germ
Species Human
ab159007 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CNOT2 Antibody Blocking Peptide - LS-E3099 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CNOT2 Antibody Blocking Peptide - LS-E11503 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CNOT2 Antibody Blocking Peptide - LS-E11201 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human CNOT2 Protein - H00004848-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human CNOT2 Protein - H00004848-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CNOT2-Antibody-Center-Blocking-Peptide - BP14239c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CNOT2 - H00004848-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CNOT2 - H00004848-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CNOT2 - H00004848-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CNOT2 - H00004848-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CNOT2 fusion protein - ag0347 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human CCR4-NOT transcription complex subunit 2(CNOT2) - CSB-YP865193HU CSB-EP865193HU CSB-BP865193HU CSB-MP865193HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CNOT2 fusion protein - Ag20553 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

CNOT2 (full length, N-term HIS tag) - TP760106 from Acris Antibodies

Category Protein
Prices $199.00
Sizes 50 µg
Source E. coli
Species Human
CNOT2

CCR4-NOT transcription complex subunit 2 (CNOT2), Recombinant Protein - MBS1381556 from MyBioSource

Category Protein
Prices $1,335.00, $1,335.00, $1,550.00, $1,550.00, $2,205.00, $2,205.00, $2,670.00, $2,670.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

CNOT2 Peptide, Human - M34GP03379H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

CNOT2 Recombinant Protein Antigen - NBP2-56034PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
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