CNOT2

Gene Symbol	CNOT2
Entrez Gene	4848
Alt Symbol	CDC36, HSPC131, NOT2, NOT2H
Species	Human
Gene Type	protein-coding
Description	CCR4-NOT transcription complex, subunit 2
Other Description	CCR4-NOT transcription complex subunit 2\|CCR4-associated factor 2\|negative regulator of transcription 2
Swissprots	Q9NSX5 Q9P028 Q9NWR6 Q9H3E0 Q9NZN8
Accessions	EAW97245 EAW97246 EAW97247 EAW97248 EAW97249 Q9NZN8 AA234384 AF044215 AAQ13426 AF113226 AAG39297 AF161480 AAF29095 AF180473 AAF29827 AK000662 BAA91313 AK095789 BAG53128 AK129966 BAC85263 AK307479 AK315715 BAG38074 AL137674 CAB70869 AY395696 AAR32245 BC002597 AAH02597 BC011826 AAH11826 BX641116 CAE46054 DA445519 DB038192 EU446948 ABZ92477 XM_006719429 XP_006719492 XM_006719430 XP_006719493 XM_006719432 XP_006719495 XM_006719433 XP_006719496 XM_011538399 XP_011536701 XM_011538400 XP_011536702 XM_011538401 XP_011536703 NM_001199302 NP_001186231 NM_001199303 NP_001186232 NM_014515 NP_055330 NR_037615
Function	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. {ECO:0000269\|PubMed:14707134, ECO:0000269\|PubMed:16712523, ECO:0000269\|PubMed:21299754, ECO:0000269\|PubMed:22367759}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:21299754}. Nucleus {ECO:0000305\|PubMed:21299754}.
Tissue Specificity	Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. {ECO:0000269\|PubMed:10637334}.
Top Pathways	RNA degradation

CNOT2 Antibody - 6955 from Cell Signaling Technology

Prices	$239.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from various cell lines using CNOT2 Antibody.

CNOT2 (L-20) - sc-82818 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CNOT2 (B-25) - sc-133470 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

CNOT2 (B-25): sc-133470. Western blot analysis of CNOT2 expression in human fetal liver tissue extract.

CNOT2 (2191C2a) - sc-81229 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

CNOT2 (2191C2a): sc-81229 Western Blot analysis of human recombinant CNOT2 fusion protein.

Anti-CNOT2 (phospho S101) antibody - ab111423 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry analysis of paraffin-embedded human brain, using CNOT2 (Phospho-Ser101) Antibody (ab111423). The picture on the right is treated with the synthesized phospho peptide.

Anti-CNOT2 antibody - ab55679 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal

Anti-CNOT2 antibody - ab79368 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CNOT2 antibody (ab79368) at 1/500 dilutionLane 1 : HepG2 cell extract, starved (24hours)Lane 2 : HepG2 cell extract, starved (24hours) with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-CNOT2 antibody - ab123261 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT2 antibody (ab123261) at 1/100 dilution + Jurkat cell line lysates

Anti-CNOT2 antibody [2191C2a] - ab51334 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2191C2a

Anti-CNOT2 Antibody (aa251-300) - LS-C109703 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

CNOT2 antibody LS-C109703 Western blot of THP-1 cell lysate.

Anti-CNOT2 Antibody - LS-C78039 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal

Anti-CNOT2 Antibody (aa441-541, clone 10B2274, Azide-free) - LS-C183504 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	10B2274

Anti-CNOT2 Antibody (aa112-161) - LS-C30876 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT2 Antibody (clone 2191C2a) - LS-C184376 from LifeSpan Bioscience

Prices	$335.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal
Clone	2191C2a

Anti-CNOT2 Antibody (aa67-116) - LS-C118368 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from HepG2 cells, treated with starved 24h, using CNOT2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CNOT2 Antibody (aa271-301, AP) - LS-C255149 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT2 Antibody (aa271-301, FITC) - LS-C255152 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT2 Antibody (aa271-301, APC) - LS-C255150 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT2 Antibody (clone 2E10) - LS-C139416 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2E10

Detection limit for recombinant GST tagged CNOT2 is approximately 3 ng/ml as a capture antibody.

Anti-CNOT2 Antibody (aa271-301, PE) - LS-C255154 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT2 Antibody (aa271-301, Biotin) - LS-C255151 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT2 Antibody (aa271-301, Azide-free, HRP) - LS-C255153 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT2 Antibody (phospho-Ser101) - LS-C198817 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded human brain, using CNOT2 (Phospho-Ser101) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-CNOT2 Antibody (aa271-301) - LS-C168887 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

CNOT2 Antibody western blot of Jurkat cell line lysates (35 ug/lane). The CNOT2 antibody detected the CNOT2 protein (arrow).

Anti-CNOT2 Antibody - LS-C309945 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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