CDKN1B

Gene Symbol CDKN1B
Entrez Gene 1027
Alt Symbol CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Species Human
Gene Type protein-coding
Description cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Other Description cyclin-dependent kinase inhibitor 1B
Swissprots Q9BUS6 Q5U0H2 P46527 Q16307
Accessions AAD14244 AAF21058 AAL78041 ABS17636 BAA76715 BAA88240 CAA59284 CAN37616 CBX53898 EAW96275 P46527 AA833962 AB451291 BAG70105 AB451423 BAG70237 AF247551 AAF69497 AJ616234 CAE82383 AK298335 BAG60584 AK312461 BAG35368 AM392564 CAL37442 AM393540 CAL38417 AM393634 CAL38510 AM393862 CAL38737 AY004255 AAF88142 BC001971 AAH01971 BG701047 BT019553 AAV38360 BT019554 AAV38361 CN311141 CR457399 CAG33680 DA948043 HY097069 HY246392 U10906 AAA20240 NM_004064 NP_004055
Function Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005}.
Subcellular Location Nucleus. Cytoplasm. Endosome {ECO:0000250}. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Top Pathways Viral carcinogenesis, Epstein-Barr virus infection, MicroRNAs in cancer, PI3K-Akt signaling pathway, Cell cycle

PathScan ® Total p27 Kip1 Sandwich ELISA Kit - 7768 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

SimpleChIP ® Human CDKN1B Promoter Primers - 11951 from Cell Signaling Technology

Category ChIP Kit
Prices $102.00
Sizes 500 µl (250 PCR reactions)
SimpleChIP ® Human CDKN1B Promoter Primers were tested on DNA isolated from cross-linked cells using the SimpleChIP ® Enzymatic Chromatin IP Kit (Magnetic Beads) #9003. Real-time PCR was performed in duplicate on a serial dilution of 2% total input DNA (20 ng, 4 ng, 0.8 ng, and 0.16 ng) using a real-time PCR detection system and SYBR ® Green reaction mix. The PCR amplification efficiency (E) and correlation coefficient (R 2 ) were calculated based on the corresponding threshold cycle (C T ) of each dilution sample during 40 cycles of real-time PCR (95°C denaturation for 15 sec, 65°C anneal/extension for 60 sec).

p27 Kip1 Human SimpleStep ELISA™ Kit - ab195211 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Sensitivity 62.5 pg/ml
Range 0.39 ng/ml - 25 ng/ml
Background-subtracted data values (mean +/- SD) are graphed.

Human CDKN1B / p27 Kip1 ELISA Kit (Custom ELISA) - LS-F466 from LifeSpan Bioscience

Category ELISA Kit
Prices $730.00, $1,290.00, $2,950.00
Sizes 1 plate, 2 plate, 5 plate
Sensitivity To be determined
Range To be determined

Human Phospho-CDKN1B / p27 Kip1 (Thr198) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1367 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-CDKN1B / p27 Kip1 (Ser10) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1585 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-CDKN1B / p27 Kip1 (Thr187) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1586 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Human CDKN1B / p27 Kip1 ELISA Kit (Cell-Based ELISA) - LS-F2203 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Human Total p27/Kip1 DuoSet IC ELISA - DYC2256-2 from R&D Systems

Category ELISA Kit
Prices $329.00, $649.00, $1,395.00
Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates)
Range 62.50 - 4,000 pg/mL

Human Total p27/Kip1 DuoSet IC, 5 Plate - DYC2256-5 from R&D Systems

Category ELISA Kit

Cyclin-dependent kinase inhibitor 1B (CDKN1B), Human, ELISA Kit - E01C1571 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Cyclin Dependent Kinase Inhibitor 1B, CDKN1B, Mouse, ELISA Kit - E-EL-M0380 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 4.688
Range 7.813-500pg/mL

CDKN1B, ELISA Kit - MBS2515515 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 4.688pg/mL
Range 7.813--500pg/mL

Cyclin dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7214721 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.

Cyclin-dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7233298 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7225466 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7252604 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7214483 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7226015 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7220648 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7217879 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7235544 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7244512 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase inhibitor 1B (CDKN1B), ELISA Kit - MBS7242733 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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