CDKN1B

Gene Symbol	CDKN1B
Entrez Gene	1027
Alt Symbol	CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Other Description	cyclin-dependent kinase inhibitor 1B
Swissprots	Q9BUS6 Q5U0H2 P46527 Q16307
Accessions	AAD14244 AAF21058 AAL78041 ABS17636 BAA76715 BAA88240 CAA59284 CAN37616 CBX53898 EAW96275 P46527 AA833962 AB451291 BAG70105 AB451423 BAG70237 AF247551 AAF69497 AJ616234 CAE82383 AK298335 BAG60584 AK312461 BAG35368 AM392564 CAL37442 AM393540 CAL38417 AM393634 CAL38510 AM393862 CAL38737 AY004255 AAF88142 BC001971 AAH01971 BG701047 BT019553 AAV38360 BT019554 AAV38361 CN311141 CR457399 CAG33680 DA948043 HY097069 HY246392 U10906 AAA20240 NM_004064 NP_004055
Function	Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005}.
Subcellular Location	Nucleus. Cytoplasm. Endosome {ECO:0000250}. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Top Pathways	Viral carcinogenesis, Epstein-Barr virus infection, MicroRNAs in cancer, PI3K-Akt signaling pathway, Cell cycle

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human p27 KIP 1 (phospho T157) peptide - ab97604 from Abcam Category Peptide

Human p27 KIP 1 full length protein - ab56279 from Abcam Category Protein Source E. coli Species Human

Human p27 KIP 1 full length protein - ab113602 from Abcam Category Protein Source E. coli Species Human

Human p27 KIP 1 full length protein - ab187214 from Abcam Category Protein Source E. coli Species Human

p27 KIP 1 peptide - ab8016 from Abcam Category Peptide

p27 KIP 1 peptide - ab116623 from Abcam Category Peptide

p27 KIP 1 peptide (153-165) - ab45884 from Abcam Category Peptide Species Human

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E2338 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E6024 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E10571 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E25214 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E8163 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E7409 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E7296 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E7297 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E7299 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E7298 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDKN1B / p27 Kip1 Antibody Blocking Peptide - LS-E26046 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human p27/Kip1 Protein - H00001027-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

p27/Kip1 Partial Recombinant Protein - H00001027-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

p27/Kip1 Partial Recombinant Protein - H00001027-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human p27/Kip1 Protein - NBP1-72503 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

p27/Kip1 Peptide - P1877 from Novus Biologicals Category Peptide Species Human

p27/Kip1 Peptide - P1661 from Novus Biologicals Category Peptide Species Human

p27/Kip1 Peptide - P1376 from Novus Biologicals Category Peptide Species Human

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