CA2

Gene Symbol	CA2
Entrez Gene	760
Alt Symbol	CA-II, CAC, CAII, Car2, HEL-76
Species	Human
Gene Type	protein-coding
Description	carbonic anhydrase II
Other Description	carbonate dehydratase II|carbonic anhydrase 2|carbonic anhydrase B|carbonic anhydrase C|carbonic dehydratase|epididymis luminal protein 76
Swissprots	Q96ET9 P00918 Q6FI12 B2R7G8
Accessions	AAA51909 CAA27012 EAW87136 P00918 AF015039 AK123309 AK312978 BAG35815 BC011949 AAH11949 BC035424 CD013933 CR536526 CAG38763 CR541875 CAG46673 DA431650 DQ891320 ABM82246 DQ894504 ABM85430 FJ224289 ACI45981 J03037 AAA51908 M36532 AAA51911 S69526 AAB30170 Y00339 CAA68426 NM_000067 NP_000058 NM_001293675 NP_001280604
Function	Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. {ECO:0000250, ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:15990874}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15990874}. Cell membrane {ECO:0000269|PubMed:15990874}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.
Top Pathways	Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Carbonic Anhydrase II full length protein - ab167716 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Human

E. coli Carbonic Anhydrase II full length protein - ab87351 from Abcam Category Protein Prices $228.00, $921.00 Sizes 100 µg, 500 µg Source E. coli Species Escherichia coli

Human Carbonic Anhydrase II full length protein - ab85484 from Abcam Category Protein Prices $188.00 Sizes 50 µg Source E. coli Species Human

Human Carbonic Anhydrase II full length protein - ab186978 from Abcam Category Protein Prices $319.00 Sizes 100 µg Source E. coli Species Human

Human Carbonic Anhydrase II peptide - ab92423 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

CA2 / Carbonic Anhydrase II Antibody Blocking Peptide - LS-E8847 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CA2 / Carbonic Anhydrase II Antibody Blocking Peptide - LS-E22002 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CA2 / Carbonic Anhydrase II Antibody Blocking Peptide - LS-E22001 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Carbonic Anhydrase II/CA2 Protein - H00000760-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Carbonic Anhydrase II/CA2 Protein - NBC1-28002 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Species Human

Carbonic Anhydrase II/CA2 Recombinant Protein - P3488 from Novus Biologicals Category Protein Prices $669.00 Sizes 100 µg Species Human

CA2-Antibody-N-term-Blocking-Peptide - BP7307a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Carbonic Anhydrase II, CF - 2184-CA-050 from R&D Systems Category Protein Source E. coli-derived, Ser2-Lys260, with C-terminal 10-His tag

Carbonic Anhydrase 2 Protein (OPPA02141) - OPPA02141 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human CA2 protein - orb244062 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

E.coli Carbonic Anhydrase 2 protein - orb90048 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli

Human Carbonic Anhydrase 2 protein - orb90049 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E.coli Species Human

Human CA2 His tag protein - orb83996 from Biorbyt Category Protein Prices $417.00, $570.00 Sizes 50 μg, 100 μg Source E. coli Species Human

CA2 Blocking Peptide - 33R-8709 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CA2 Blocking Peptide - 33R-2905 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Carbonic anhydrase II protein - 30R-1325 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

Carbonic Anhydrase 2 Blocking Peptide - abx062314 from Abbexa Category Peptide Species Human, Rat, Monkey

Human Carbonic Anhydrase II Protein - abx065684 from Abbexa Category Protein Source E.coli Species Human

Human Carbonic Anhydrase II Protein - abx065685 from Abbexa Category Protein Source E.coli Species Human

Human Carbonic Anhydrase II Protein - abx065686 from Abbexa Category Protein Source E.coli Species Human

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