| Gene Symbol |
KRT28
|
| Entrez Gene |
162605
|
| Alt Symbol |
KRT25D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin 28, type I
|
| Other Description |
CK-28|K25D|K28|cytokeratin-28|keratin 25D|keratin, type I cytoskeletal 28|keratin-25D|keratin-28|type I inner root sheath specific keratin 25 irs4|type I inner root sheath-specific keratin-K25irs4
|
| Swissprots |
Q6ZP84 Q7Z3Y7
|
| Accessions |
EAW60679 Q7Z3Y7 AJ564207 CAD91907 AK129827 BAC85240 BC146368 AAI46369 BC148794 AAI48795 NM_181535 NP_853513
|
| Function |
Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs). {ECO:0000250|UniProtKB:A6BLY7}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:A6BLY7}.
|
| Tissue Specificity |
Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level). {ECO:0000269|PubMed:15617563, ECO:0000269|PubMed:16874310}.
|