Gene Symbol | KRT28 |
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Entrez Gene | 162605 |
Alt Symbol | KRT25D |
Species | Human |
Gene Type | protein-coding |
Description | keratin 28, type I |
Other Description | CK-28|K25D|K28|cytokeratin-28|keratin 25D|keratin, type I cytoskeletal 28|keratin-25D|keratin-28|type I inner root sheath specific keratin 25 irs4|type I inner root sheath-specific keratin-K25irs4 |
Swissprots | Q6ZP84 Q7Z3Y7 |
Accessions | EAW60679 Q7Z3Y7 AJ564207 CAD91907 AK129827 BAC85240 BC146368 AAI46369 BC148794 AAI48795 NM_181535 NP_853513 |
Function | Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs). {ECO:0000250|UniProtKB:A6BLY7}. |
Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:A6BLY7}. |
Tissue Specificity | Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level). {ECO:0000269|PubMed:15617563, ECO:0000269|PubMed:16874310}. |
Keratin 28 CRISPR/Cas9 KO Plasmid (h) - sc-407163 from Santa Cruz Biotechnology
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Keratin 28 HDR Plasmid (h) - sc-407163-HDR from Santa Cruz Biotechnology
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Keratin 28 Double Nickase Plasmid (h) - sc-407163-NIC from Santa Cruz Biotechnology
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Keratin 28 Double Nickase Plasmid (h2) - sc-407163-NIC-2 from Santa Cruz Biotechnology
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Keratin 28 CRISPR Activation Plasmid (h) - sc-407163-ACT from Santa Cruz Biotechnology
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Keratin 28 CRISPR Activation Plasmid (h2) - sc-407163-ACT-2 from Santa Cruz Biotechnology
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Keratin 28 Lentiviral Activation Particles (h) - sc-407163-LAC from Santa Cruz Biotechnology
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Keratin 28 Lentiviral Activation Particles (h2) - sc-407163-LAC-2 from Santa Cruz Biotechnology
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Keratin 28 siRNA (h) - sc-94189 from Santa Cruz Biotechnology
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Keratin 28 shRNA Plasmid (h) - sc-94189-SH from Santa Cruz Biotechnology
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Keratin 28 shRNA (h) Lentiviral Particles - sc-94189-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU145251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11376 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11376 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01021 from Sigma-Aldrich
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KRT28 siRNA (Human) - CRJ5956 from Cohesion Biosciences
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shRNA set against Human KRT28 (NM_181535.3) - SHH327419 from Creative biogene
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Human KRT28 siRNA - orb276457 from Biorbyt
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KRT28 shRNA Plasmid (Human) - CHJ5956 from Cohesion Biosciences
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KRT28 miRNA 3'UTR clone - MiUTR1H-05449 from Creative biogene
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