FLT1

Gene Symbol	FLT1
Entrez Gene	2321
Alt Symbol	FLT, FLT-1, VEGFR-1, VEGFR1
Species	Human
Gene Type	protein-coding
Description	fms-related tyrosine kinase 1
Other Description	fms-like tyrosine kinase 1|fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)|tyrosine-protein kinase FRT|tyrosine-protein kinase receptor FLT|vascular endothelial growth factor receptor 1|vascular permeability factor receptor
Swissprots	F5H5L6 B2BF48 A8KA71 A3E342 B0LPF1 B3FR89 O60722 P16057 A3E344 Q12954 B2BF46 B5A923 P17948 B2BF47
Accessions	ABY87530 AGC09589 AGL73885 AGL73886 AGS56393 AGS56394 AHC08482 AHC08483 AHC08484 AHC08485 AHC08486 AHC08487 AHC08488 AHC08489 AHO49114 AHO49115 AHO49116 AHO49117 BAA00080 CAH56859 CAJ33638 CBW44131 EAX08431 EAX08432 P17948 AB209050 BAD92287 AF063657 AAC16449 AK092472 AK292936 BAF85625 AK300392 BAG62125 AK309901 BC029849 BC039007 AAH39007 BE180461 BU151621 BX504049 CA396081 DA844548 DA851664 DQ836394 ABI53803 DQ836395 ABI53804 DQ836396 ABI53805 EF484674 EF491868 ABS32268 EF491869 ABS32269 EF491870 ABS32270 EU360600 ACB05747 EU368830 ACA62948 EU443152 ACA21474 EU826561 ACF47597 EU826562 ACF47598 JF509744 AFC77954 JF509745 AFC77955 S77812 AAB34001 S77814 AAB34002 U01134 AAC50060 XM_011535014 XP_011533316 NM_001159920 NP_001153392 NM_001160030 NP_001153502 NM_001160031 NP_001153503 NM_002019 NP_002010
Function	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane
Subcellular Location	Isoform 7: Cytoplasm {ECO:0000305}.
Tissue Specificity	Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC). {ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:20512933}.
Top Pathways	Cytokine-cytokine receptor interaction, Focal adhesion, Endocytosis, Rheumatoid arthritis, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® VEGF Receptor 1 Kinase Assay Kit - 7785 from Cell Signaling Technology Category Assay Kit

VEGF R1 (FLT1) Human ELISA Kit - ab119613 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 30 pg/ml Range 156 pg/ml - 10000 pg/ml

VEGF R1 (FLT1) Human ELISA Kit - ab119567 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity 0.03 ng/ml Range 0.16 ng/ml - 10 ng/ml

VEGF R1 (FLT1) Human SimpleStep ELISA™ Kit - ab195210 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 146 pg/ml Range 0.391 ng/ml - 25 ng/ml

Mouse FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F4452 from LifeSpan Bioscience Category ELISA Kit Prices $460.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 78.13-5000 pg/ml

Rat FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F6360 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 78.13-5000 pg/ml

Pig FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F6396 from LifeSpan Bioscience Category ELISA Kit Prices $820.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 78.13-5000 pg/ml

Human FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F2571 from LifeSpan Bioscience Category ELISA Kit Prices $540.00 Sizes 1 plate Sensitivity 30 pg/ml Range 78.13-5000 pg/ml

Human FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F4997 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 32 pg/ml Range 78.13-5000 pg/ml

Human FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F661 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 78.13-5000 pg/ml

Mouse FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F303 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 4.113 pg/ml Range 78.13-5000 pg/ml

Rat FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F12941 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 Range 78.13-5000 pg/ml

Mouse FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F12943 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 78.13-5000 pg/ml

Human FLT1 / VEGFR1 ELISA Kit (Sandwich ELISA) - LS-F12942 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.312 Range 78.13-5000 pg/ml

Mouse VEGF R1 ELISA Kit - RAB0192 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human VEGF R1/Flt-1 Quantikine ELISA Kit - DVR100B from R&D Systems Category ELISA Kit Prices $519.00, $2,491.00, $16,868.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 13.3 pg/mL Range 31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Saliva, Follicular Fluid)

Human VEGF R1/Flt-1 Quantikine PharmPak (50 Plates), 2nd Gn - PDVR100B from R&D Systems Category ELISA Kit Sensitivity 13.3 pg/mL Range 31.2 - 2,000 pg/mL (Serum, Saliva, Cell Culture Supernates, EDTA Plasma, Follicular Fluid)

Human VEGF R1/Flt-1 Quantikine SixPak (6 Plates) - SVR100B from R&D Systems Category ELISA Kit Sensitivity 13.3 pg/mL Range 31.2 - 2,000 pg/mL (Serum, Saliva, Cell Culture Supernates, EDTA Plasma, Follicular Fluid)

Mouse VEGF R1/Flt-1 Quantikine ELISA Kit - MVR100 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 15.2 pg/mL Range 125.0 - 8,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma)

Mouse sVEGF R1/Flt-1 DuoSet ELISA - DY471 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 156.00 - 10,000 pg/mL

Human VEGF R1/Flt-1 DuoSet ELISA - DY321B from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Human Phospho-VEGF R1/Flt-1 DuoSet IC ELISA - DYC4170-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates)

Human Phospho-VEGF R1/Flt-1 DuoSet IC, 5 Plate - DYC4170-5 from R&D Systems Category ELISA Kit

Human VEGFR1 ELISA kit - 55R-IB49657 from Fitzgerald Category ELISA Kit Prices $825.00 Sizes 96 wells

Human VEGFR1 ELISA kit - 55R-1703 from Fitzgerald Category ELISA Kit Prices $405.00 Sizes 1 kit

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