| Gene Symbol |
FLT1
|
| Entrez Gene |
2321
|
| Alt Symbol |
FLT, FLT-1, VEGFR-1, VEGFR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fms-related tyrosine kinase 1
|
| Other Description |
fms-like tyrosine kinase 1|fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)|tyrosine-protein kinase FRT|tyrosine-protein kinase receptor FLT|vascular endothelial growth factor receptor 1|vascular permeability factor receptor
|
| Swissprots |
F5H5L6 B2BF48 A8KA71 A3E342 B0LPF1 B3FR89 O60722 P16057 A3E344 Q12954 B2BF46 B5A923 P17948 B2BF47
|
| Accessions |
ABY87530 AGC09589 AGL73885 AGL73886 AGS56393 AGS56394 AHC08482 AHC08483 AHC08484 AHC08485 AHC08486 AHC08487 AHC08488 AHC08489 AHO49114 AHO49115 AHO49116 AHO49117 BAA00080 CAH56859 CAJ33638 CBW44131 EAX08431 EAX08432 P17948 AB209050 BAD92287 AF063657 AAC16449 AK092472 AK292936 BAF85625 AK300392 BAG62125 AK309901 BC029849 BC039007 AAH39007 BE180461 BU151621 BX504049 CA396081 DA844548 DA851664 DQ836394 ABI53803 DQ836395 ABI53804 DQ836396 ABI53805 EF484674 EF491868 ABS32268 EF491869 ABS32269 EF491870 ABS32270 EU360600 ACB05747 EU368830 ACA62948 EU443152 ACA21474 EU826561 ACF47597 EU826562 ACF47598 JF509744 AFC77954 JF509745 AFC77955 S77812 AAB34001 S77814 AAB34002 U01134 AAC50060 XM_011535014 XP_011533316 NM_001159920 NP_001153392 NM_001160030 NP_001153502 NM_001160031 NP_001153503 NM_002019 NP_002010
|
| Function |
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane
|
| Subcellular Location |
Isoform 7: Cytoplasm {ECO:0000305}.
|
| Tissue Specificity |
Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC). {ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:20512933}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Focal adhesion, Endocytosis, Rheumatoid arthritis, PI3K-Akt signaling pathway
|